潘 增 刚, MD, PhD

学历学位：病理学医生，病理学博士

现在职称：病理学副教授

专业方向：血液病理学，普通外科病理学

现在单位：美国耶鲁大学病理学系

电子邮箱：zenggang.pan@yale.edu

个人网站：www.enjoypath.com

学习和工作经历：

·  2018 －现在：美国耶鲁大学病理学系，副教授

·  2012 －2018：美国科罗拉多大学病理学系，助理教授

·  2011－2012：美国加州City of Hope医学中心，血液病理学专科培训

·  2010－2011：Alabama大学病理学系，外科病理学专科培训

·  2006－2010：美国Creighton大学医学中心，解剖病理和临床病理，住院医培训

·  2000－2006：美国Nebraska大学医学中心和淋巴瘤研究中心，病理学博士

·  1997－2000：北京医科大学病理学系，助教、病理住院医和淋巴瘤研究

·  1996－1997：北京医科大学病理学系，淋巴瘤实验室，本科毕业课题设计

·  1992－1997：北京医科大学，医学本科

病理学博士期间的主要工作：在血液病理学家Wing C. (John) Chan 的指导下，从生发中心B细胞以及相关淋巴瘤中克隆了两个新的基因，GCET1和 GCTE2/HAGL， 现已应用于淋巴瘤的分类和研究。

现在主要科研兴趣：淋巴瘤和白血病诊断和分类；淋巴瘤微环境在肿瘤的发生，分类，发展，和治疗中的意义。

主要发表文章：

·     Jane Yuan, Shaoying Li, Xin Liu, Ruijun Su, Mingyi Chen, Xiaojun Wu, Gang Zheng, Lynette Smith, Lifu Wang, Yanxia Li, Cynthia Liu, Jiehao Zhou, Qi Shen, Linsheng Zhang, Endi Wang, Mina Xu, and Zenggang Pan. Mantle cell lymphoma with mantle zone growth pattern: an indolent and often incidental lymphoma. (Corresponding author. In revision. American Journal of Clinical Pathology)

·     Virginia Knez, Xin Liu, Jeff Schowinsky, Zenggang Pan, Dehua Wang, Robert Lorsbach, Chuanyi M Lu, Catherine Luedke, Mary Haag, Billie Carstens, Lianhe Yang, Rachel Jug, Endi Wang, and Xiayuan Liang. Clinicopathologic and Genetic Spectrum of Infantile B-Lymphoblastic Leukemia: A Multi-Institutional Study. Leukemia and Lymphoma. 2018 September 6:1-8

·     Carrie B. Coleman, Julie Lang, Lydia A. Sweet, Nicholas A. Smith, Brian M. Freed, Zenggang Pan, Bradley Haverkos, Roberta Pelanda, Rosemary Rochford. Epstein-Barr virus type-2 infects T-cells and induces B-cell lymphomagenesis in humanized mice. Journal of Virology. 2018 August 8

·     Ansuman T. Satpathy, Ryanne A. Brown, Ellen Gomulia, Carlos G. Briseno, Maxwell R. Mumbach, Zenggang Pan, Kenneth M. Murphy, Yasodha Natkunam, Howard Y. Chang, and Jinah Kim. Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of dendritic cell origin. Modern Pathology. 2018 May 9

·     Zenggang Pan, Mingyi Chen, Qianyun Zhang, Endi Wang, Liqun Yin, Youyuan Xu, Qin Huang, Xiaohui Zhang, Gang Zheng, and Ji Yuan. CD3-Positive Plasmablastic Lymphoma and Plasmablastic Plasma Cell Neoplasm: A Diagnostic Pitfall.  Modern Pathology. 2018 January 12 (Corresponding Author)

·     Zenggang Pan, Bette Kay Kleinschmidt-DeMasters. CNS Erdheim-Chester Disease: A Challenge to Diagnose. Journal of Neuropathology and Experimental Neurology. 2017 December 1;76(12):986-996

·     Xiaoguang Wang, Zhangguo Chen, Ameet K. Mishra, Alexa Silva, Zenggang Pan, Jing H. Wang. Chemotherapy-induced differential cell cycle arrest in B cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica. 2017, December 7

·     Zenggang Pan, Jiehao Zhou. IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. International Journal of Clinical and Experimental Pathology. 2017;10(10):10153-10166 (Corresponding Author)

·     Christopher Melani, Ajay Major, Jeffrey Schowinsky, Mark Roschewski, Stefania Pittaluga, Elaine S. Jaffe, Svetlana D. Pack, Zied Abdullaev, Mark A. Ahlman, Jennifer J. Kwak,  Rustain Morgan, Rachel Rabinovitch, Zenggang Pan, Bradley M. Haverkos, Jonathan A. Gutman, Daniel A. Pollyea, Clayton A. Smith, Wyndham H. Wilson, Manali Kamdar. PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. New England Journal of Medicine. 2017 July 6;377(1):89-91

·     Zenggang Pan, Shimin Hu, Min Li, Yi Zhou, Young S. Kim, Vishnu Reddy, Mingyi Chen, Zifen Gao, Huan-You Wang, Ji Yuan. ALK-positive diffuse large B-cell lymphoma: A clinicopathologic study of 26 cases with review of additional 108 cases in the literature. American Journal of Surgical Pathology. 2017 January;41(1):25-38

·     Liqun Yin, Jie Xu, Min Li, Vishnu Reddy, Quan Zhou, Huanxin Liu, Peiguo Chu, Qianyun Zhang, Qin Huang, Zifen Gao, Huanyou Wang, Xiayuan Liang, and Zenggang Pan. BOB1 and OCT2 Expression in Lineage Determination of B-Cell Lymphomas Negative for Conventional B-Cell Markers. Histopathology. 2016 November;69(5):775-783 (Corresponding Author)

·     Bradley M. Haverkos, Zenggang Pan, Alejandro A. Gru, Aharon G. Freud, Rachel Rabinovitch, Meng Welliver, Brad Otto, Carlos Barrionuevo, Robert A. Baiocchi, Rosemary Rochford , and Pierluigi Porcu Extranodal NK/T-cell lymphoma (ENKTL): an update on epidemiology, clinical presentation, and natural history in North American and European cases. Current Hematologic Malignancy Reports. 2016 December;11(6):514-527 (Review Article)

·     Zenggang Pan, Yuanyuan Chen, Xiaojun Wu, Vijay Trisal, Sharon Wilczynski, Peiguo Chu, Huiqing Wu. Merkel Cell Carcinoma of Lymph Node with Unknown Primary Has a Significant Lower Association with Merkel Cell Polyomavirus Than Its Cutaneous Counterpart. Modern Pathology 2014 Sep;27(9):1182-1192

·     Zenggang Pan, Qingmei Xie, Susan Repertinger, Bill G. Richendollar, Wing C. Chan, and Qin Huang. Plasmablastic Lymphomas Directly Transformed from Chronic Lymphocytic Leukemia with Newly Acquired C-Myc Gene Rearrangement. Human Pathology. 2013 October;44(10):2139-2148.

·     Zenggang Pan, William Grizzle, and Omar Hameed. Immunohistochemical Expression of Renal Markers in Matched Primary and Metastatic Renal Cell Carcinomas. American Journal of Clinical Pathology. 2013 September;140(3):410-418 (Original article with SAM questions)

·     Zenggang Pan, Qianyun Zhang, Zhengbin Lu, Tobi Quinto, Igor B. Rozenvald, Lanting Liu, David Wilson, Vishnu Reddy, Huanyou Wang, Yongsheng Ren. Extracavitary KSHV-Associated Large B-Cell Lymphoma: A Distinct Entity or a Subtype of Primary Effusion Lymphoma? Study of 9 Cases and Review of Additional 43 Cases. American Journal of Surgical Pathology. 2012 August;36(8):1129-1140.

·     Zenggang Pan, Yulei Shen, Baosheng Ge, Cheng Du, Timothy McKeithan, Wing C. Chan. Studies of a Germinal Center B-cell Expressed Gene, GCET2, Suggest its Role as a Membrane Associated Adapter Protein. British Journal of Hematology. 2007 June; 137(6):578-590.

·     Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Wing C. Chan, Patricia Aoun, Gregory T. Cochran, Zenggang Pan, Lynette M. Smith, James C. Lynch, Robert Gregory Bociek, Philip J. Bierman, Julie M. Vose and James O. Armitage. Expression of PKC-beta or Cyclin D2 Predicts for Inferior Survival in Diffuse Large B-Cell Lymphoma. Modern Pathology. 2005 October; 18(10):1377-1384.

·     Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Randy D. Gascoyne, Jan Delabie, German Ott, H. Konrad Müller-Hermelink, Elias Campo, Rita M. Braziel, Elaine S. Jaffe, Zenggang Pan, Pedro Farinha, Lynette M. Smith, Brunangelo Falini, Alison H. Banham, Andreas Rosenwald, Louis M. Staudt, Joseph M. Connors, James O. Armitage, and Wing C. Chan. Confirmation of the Molecular Classification of Diffuse Large B-Cell Lymphoma by Immunohistochemistry Using a Tissue Microarray. Blood. 2004 January 1; 103(1):275-282.

·     Zenggang Pan, Yulei Shen, Cheng Du, Guimei Zhou, Andreas Rosenwald, Louis M. Staudt, Timothy C. Greiner, Timothy W. McKeithan and Wing C. Chan. Two Newly Characterized Germinal Center B-Cell Associated Genes, GCET1 and GCET2, Have Differential Expression in Normal and Neoplastic B-cells. The American Journal of Pathology. 2003 July; 163(1):135-144.

·     Sanjana Mehrotra, Zenggang Pan. Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: A case of transdifferentiation from low-grade follicular lymphoma. Diagnostic Cytopathology 2015 Aug;43(8):659-663.

·     Kathryn D. Matney, Lynne Meltesen, Karen Swisshelm, Zenggang Pan. Novel Report of a Clonal Myeloproliferative Disorder with Prominent Histiocytic Differentiation. Ann Clin Pathol 2014; 2(5): 1034.

·     Zenggang Pan, Warren G. Sanger, Julia A. Bridge, William J. Hunter, Gene P. Siegal and Shi Wei. A Novel t(6;13)(q15;q34) in a Giant Cell Reparative Granuloma. Human Pathology. 2012 June;43(6):952-957.

·     Shi Wei*, Zenggang Pan*, Gene P. Siegal, et al. Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts. Human Pathology. 2012 January;43(1):121-126. (*Equal contribution)

·     Zifen Gao, Fen Jiang, Zenggang Pan. P53 Gene Mutation and EBV Associated Nasopharyngeal T-Cell Lymphoma. The Chinese Journal of Clinical Oncology. 1999 November; 26(6); 429-432.

·     Zifen Gao, Faith Ho, Zenggang Pan. Comparative Studies of Nasopharyngeal B-Cell Lymphomas in Hong Kong and Beijing. Journal of Beijing Medical University. 1999 February; 31(2):42-44.

·     Zifen Gao, Honghai Wang, Zenggang Pan. Investigation of the Clinicopathologic Features, Immunophenotype and Epstein - Barr virus Infection of the Upper Respiratory Tract Lymphomas. The Chinese Journal of Pathology. 1998 August; 27(4):251-254