王丽娜, M.D. M.S.美国加利福尼亚州洛杉机南加州大学病理系病理资深主治医生， 助理教授，主要从事外科病理工作。现任南加州大学病理系乳房病理和泌尿外科病理专家。除专长外科病理诊断之外， 还从事医学生和住院医师教学工作。

现主要科研方向为乳腺癌、 肺癌、泌尿外科肿瘤病理的研究。对软组织肿瘤、肾肿瘤和血液病分子遗传病理学感兴趣。

Research Grants

Current

1. V-foundation grant (Oct 31, 2013-Oct 30-2016) PI: Ite Laird_ Offringa (a 3-year grant aimed at developing immunotherapy for SCLC).

SPECIFIC AIMS

The project has three specific aims:

Aim 1. To develop an immunization protocol for mice using native or isoaspartylated HuD.

Aim 2a. To modify the existing SCLC mouse model to accurately mimic human SCLC response to

cisplatin/etoposide (C/E) treatment, remission and ultimately cancer recurrence.

2b. To use this model to test the therapeutic efficacy of anti-HuD immunization.

Aim 3. To determine the optimal time to treat human SCLC patients with immunotherapy by assessing the

immune status of 10 patients prior to C/E treatment and at 3 weeks and 6 weeks after their final cycle.

Role: Co-PI

$600,000

Completed

1. Gingiva Derived MSCs: Role in Immunomodulation and Tissue Regeneration, R01 DE019932, NIH, PI: Anh Le, 2009-2014

Role: Consultant $3,000,459

2 HIV infection of cervical epithelia exposed to alcohol, Alcohol grant (AA-03-0004) ), PI: Anh Le, 2003-2005

Role: Consultant $1,250,000

3. Epidemiology, genetic and molecular biology studies of keloids (1 P01 AR051950-01) (multi-PI), PI: Anh Le, 2004-2005

Role: Consultant $1,000,000

4. Rice Brand Extract Enhances Yeast-Induced Cancer Apoptosis.  Grant No. 1AO1CA109048-01, PI : Mamdooh Ghoneum, 2006-2008

Role: Consultant $961,875

over 3 years

5. HPV and Susceptibility Biomarkers in Oral Pre-Cancer, R03 CA 128099-01, NCI, PI: Anh Le, 2007-2009

Role: Consultant $163,000

1978-1983  青岛医学院，医学学士 (本科)

1983-1987  青岛医学院药理系助教

1987-1990  青岛医学院免疫/药理学, 硕士

1990-1996  加州大学洛杉矶分校内科和儿科免疫学助理研究员

1996-2000  Harbor-UCLA Medical Center, 临床和外科病理系住院医生和住院总 (Chief Resident)

2000年通过美国国家病理医生认证资格考试（America Board Certified in AP, CP）

2000-2001 南加州大学外科病理研究员

2001-2002 南加州大学细胞学病理研究员

2002通过美国国家病理医生认证资格考试（America Board Certified in Cytopathology）

2002-2005 King-Drew医学中心细针穿刺和免疫实验室主任

2001-2004  Impath病理顾问

2007-2010 genzyme病理高级顾问

2013 Philips病理高级顾问

2005年至今：美国加利福尼亚州洛杉机南加州大学病理系助理教授

2001年获得南加州大学旅游奖，洛杉矶病理学会论文优秀奖,并受邀参加过多个国内和国际会议。现为美国加拿大病理学会，美国临床科学家协会, 中美病理协会会员。

Peer Reviewed publications:

Wang L, Shao B, Yan Y.  Anti-inflammatory and analgesic actin of 3B-C1.  Chinese Pharmacological Communication 3-4:220-1, 1984

Wang L, Yan Y.  Primary studies on anti-inflammatory effects of crystals of rabdosiasawlponeata (Vaniot) Hava.  Communication of Special Society of National Anti-inflammatory and Immunology Pharmacology 26:6, 1985

Liu L, Wang L, Ganz T.  Structure and mapping of the human β-defensin HBD-2 gene and its expression at the site of inflammation.  Gene 222:273-244, 1998

Wang L, Tabbarah HJ, French SW.  Gastric adenocarcinoma with a yolk sac component: A case report and review of the literature.  J Clin Gastroenterology 31(1):85-8, 2000

Wang L, Vargas H, French SW.  Cellular origin of gastrointestinal stromal tumors.  Arch Pathol Lab Med 124(10):1471-5, 2000

Egger B, Cai NN, Wang L, French SW, Bucher MW, Eysselein VE.  Transforming growth factor-alpha (TGF-α) is not needed for malignant transformation in experimental colitis.  Scand J Gastroenterology 36:276-282, 2001

Wang X, Morgan T, Lungo W, Wang L, French SW.  Piecemeal necrosis: Renamed Troxis Necrosis.  ExpMolPathol 71:137-146, 2001

Wang L, Cornford M.  Coincident choroid plexus carcinoma and adenocortical carcinoma with elevated p53 expression: A case report of an 18-month-old boy with no family history of cancer.  Arch Pathol Lab Med 126(1):70-73, 2002

Wang L, Ohara JA, Cote RJ.  Pathology quiz case:  41-year-old woman with bilateral nodular breasts.  Arch Pathol Lab Med 126(2):223-4, 2002

Wang L, Felix JC, Lee JL, Tan PY, Tourgeman DE, O’Meara AT, Amezcua CA.  The proto-oncogene c-kit is expressed in leiomyosarcomas of the uterus.  Gynecologic Oncology 90:402-6, 2003

Ching B, Klink A, Wang L.  Pathology quiz case: 22-year-old female with a large right adnexal mass.  Arch Pathol Lab Med 128(7):93-95, 2004

Choi H, Cornford ME, Wang L, Sun J, Friedman TC.  Suprasellar mass with panhypopituitarism in acute Chagas disease.  Pituitary 7:111-114, 2004

Wang L, Sherrod A, Warner N.  Pathology quiz case: 79-year-old woman with a black, ulcerated cecal tumor and three negative Guaiac test results.  Arch Pathol Lab Med 129(1):113-4, 2005

Zhang Q, Oh CK, Messadi DV, Duong HS, Kelly AP, Soo C, Wang L, Le AD.  Hypoxia-induced HIF-1 an accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: Involvement of ERK1/2 and PI-3K/AKt. Exp Cell Res. 312(2):145-55, Jan 15 2006

Zhang Q, Kelly AP,Wang L, French SW, Tang X, Duong HS, Messadi DV, Le AD.  Green Tea Extract and (-)-Epigallocatechin-3-gallate Inhibit Mast cell-stimulated Type I Collagen Expression in Keloid Fibroblasts via Blocking PI-3K/Akt Signaling Pathway. J Invest Dermatol. 126(12):2607-13, Dec 2006. Epub Jul 13, 2006

Ghoneum M, Wang L, Agrawal S, Gollapudi.S.  Yeast therapy for the treatment of breast cancer: a nude mice model study. In vivo 21:251-258, 2007

Zhang Q, Yamaza T, Kelly AP, Shi S, Wang S, Brown J, Wang L, French SW, Shi S, Le AD.  Tumor-Like Stem Cells Derived from Human Keloid Are Governed by the Inflammatory Niche Driven by IL-17/IL-6 Axis. PloS ONE 4 (11): e7798. Pages 1-32, Nov 11 2009

Whang TB, Wang L, Peng DH.  Gastric carcinoma of the umbilicus: case report of sister mary nodule. Cutis 85:90-92, 2010

Xu T, He K, Wang L, Goldkorn A.  Prostate tumor cell with cancer progenitor properties have high telomerase activity and rapidly killed by telomerase interference. Prostate. Feb. 2011. Published online in Wiley Online Library, DOI 10.1022/pros.

Fairey AS, Daneshmand S, Wang L, Schuckman A, Lieskovsky G, Djaladat H, Cai J,  Miranda G, Skinner EC. Impact of micropapillaryurothelial carcinoma variant histology on survival after radical cystectomy.Urologic Oncology http://www.researchgate.net/journal/1873-2496_Urologic_Oncology(Impact Factor: 3.65). 03/2013; DOI:10.1016/j.urolonc.2012.04.020

Abstracts:

Wang L, Shao B, Yan Y.  Anti-inflammatory and immunology inhibitory effects of Sedoprosanum, 5th Southeast Asian and Western Pacific Regional Meeting of Pharmacologists, Beijing, China, July 4-8, 1988 (Poster presentation)

Edelstein MA, Sze GS, Wang L, French SW, Eysselein VE, Vargas H.Endoscopic ultrasonography (EUS) staging of primary gastric adenocarcinoma (G1744).  Gastroenterology 116:4 Part 2: A398, 1999 (Poster)

Khaleg AM, Sze GS, Eysselein VE, Wang L, French SW.  An algorithm for staging pancreatic adenocarcinoma and predicting resectability using endosonography (EUS) (G1911).  Gastroenterology 116:4 Part 2:A435, 1999 (Poster)

Egger B, Cai NN, Wang L, French SW, Eysselein VE.  Transforming growth factor-alpha (TGF-α) is a key mediator in protection and/or repair mechanisms but is not required for tumor formation in murine chronic dextran sulfate colitis (G3067).  Gastroenterology 116:4 Part 2:A705, 1999 (Poster)

Wang L, Vargas H, Kakuda J, Wang E, French SW.  Origination of gastrointestinal stromal tumors: Study of 23 cases.  Am J ClinPathol 112:542-3, 1999 (Poster presentation)

French SW, Lungo W, Wang L, Wang J, Wang X.  Piecemeal necrosis in hepatitis C: A morphologic analysis.  Hepatology 30(4): 335A, 1999 (Poster)

Wang L, McPhaul L, Felix J, Amezcua C, French SW  C-kit expression in smooth muscle tumor.  Am J ClinPathol 116:609, 2001 (Poster)

Wang L, Greaves TS, Berberrian K, Cobb CJ.The diagnostic utility of parotid gland FNA as a toll for surgical triage.  Lab Invest 82(1): 91A, 2002 (Poster)

Wang L, Felix JC, Amezcua CA.  The pattern of expression of c-kit and CD10 may aid in the diagnostic distinction among uterine mesenchymal neoplasms.  Lab Invest 82(1): 213A, 2002 (Poster presentation)

Wang L, Williams AS, Groshen S, Nichols PW, Cote R.  HER-2/neu expression in bladder micropapillary transitional cell carcinoma: A potential target for therapy.  Am J ClinPathol 118:657-8, 2002 (Poster)

Wang L, Messadi D, Kelly P, Le A, French SW.  Role of mast cells in keloid pathogenesis.  United States and Canadian Academy of Pathology 93rd Annual Meeting, Vancouver, BC, Canada, March 6-12, 2004

Vu TH, Wang L, Liu RW, Sun J.  A tale of two tumors.  Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Liu RW, Sun J, Owens J, Vu TH, Wang L.  Chondrosarcoma of the skull base.  Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Bolton D, Wang L, Klink A, Liu RW, Vu TH.  Rhabdomyosarcoma: A nineteen-year-old female presenting with respiratory failure.  Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Ching B, Klink A, Wang L.  22-year-old female with a large right adnexal mass.  Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Zhang Q, Tang X, Duong HS, Kelly AP, Soo C, Wang L, Le AD. Altered functions of keloid fibroblasts co-cultured with mast cells under both normoxic and hypoxic conditions. October 2005 (Poster)

Wang L, Zhang Q, Kelly AP,French SW, Tang X, Duong HS, Messadi DV, Le DV.  Green tea extract and (-)-epigallocatechin-3- gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/Akt signaling pathway. The Pathologists’meeting CAP 2006 in San Diego, California, 2006 (Poster presentation)

Chan V and Wang L. Signet ring cell sinus histiocytosis of lymph node mimicking metastatic signet ring cell adenocarcinoma. The Pathologists’ meeting CAP 2007, Chicago, IL, Sept. 30-Oct. 3, 2007 (Poster)

Fairey AS, Yang D, Groshen SG, Kim P, Virk N, Wang L, Martin SE, Stephens C, Cooc J, Goldkorn A. Association between cancer stem-like cell gene expression and clinical outcome in localized prostate cancer: A nested case-control study. 2012 Genitourinary Cancers Symposium (February 2-4, 2012). Abstract # 89775 (Poster presentation).Received ASCO-GU Merit Award.

Hu BR, Fairey AS, Yang D, Li M,  Groshen SG, Stephens C, Quinn ID, Kim P, Virk N, Wang L, Martin SE, Gill SI, Goldkorn A. AXIN2 and prostate cancer recurrence after radical prostatectomy. 2014 Genitourinary Cancers Symposium (January 30-February 1, 2014 | San Francisco Marriott Marquis | San Francisco, CA Abstract # 123827 (Poster presentation).

Poole B, Wecsler J, Sheth P, Sener SF, Tripathy D, Yamashita M, Wang L, Russell C, Johnson M, Larson l, Lang EL. Contemporary Upgrade Rates on Excisional Breast Biopsy for Radiology-Pathology Discordant Core Biopsies, accepted for a poster presentation at the American