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李昕


李昕: MD, PhD
主治医师，2012年七月加入美国里士满大学医学中心
简历：
2011年7月至2012年六月：美国匹兹保大学医学院做研究员，研究乳腺/妇科病理
2010年7月至2011年6月；美国托莱多大学医学中心，任总住院医师
2007年7月至/20116月：美国托莱多大学医学中心，住院医师
1996年4月至2000年3月；日本山梨医科大学 病理形态学博士
1986年至1989年：中国辽宁沈阳医科大学，肿瘤病理硕士
1981年1986年；中国辽宁沈阳医科大学，临床医学专业医学生
专业资格：
2011年获得美国病理学委员会：美国病理学委员会组织病理和临床病理资格证书；目前具有俄亥俄州医师资格证书：35.096311, 有效期: 7/1/2014
宾夕法尼亚州医师资格证书: MT198748, 有效期： 6/30/2012
行政和社会活动：
2011年至今：美国和加拿大病理学协会
2007年至今：美国病理学协会成员
2007年至今：美国临床病理学协会
2004年：加入内分泌协会
2001年至2003年：加入细胞病理学协会
1998年至2000年：加入日本组织、细胞化学协会
1996年至1997年：加入日本病理学协会
1989年至1995年：加入中国抗癌协会
获奖、荣誉：
2010年：获得俄亥俄州病理学会Donald Senhauser住院医生竞赛决赛提名
2002年至2004年：获得国防部博士后助学金
2000年:在日本山梨大学授博士学位典礼上参加演说
1995年至2000年：获得日本政府奖学金(Monbusho)
1998年：日本组织、细胞化学协会授予年轻研究员
1998年：美国组织化学协会与日本组织、细胞化学协会第5次联合会议授予学生奖
工作经历：
1992年9月至1995年1月：在中国医科大学癌症研究所任主治医师
1989年9月至1992年8月：在中国医科大学癌症研究所任病理住院医师
教学经历：
2007年7月至2011年6月：在美国托莱多医疗中心任病理系教师
1999年4月至2000年4月：在日本山梨医科大学任病理系教师
研究经历：
2003年10月至2007年6月：美国凯斯西部保留地大学，助理研究员
2000年4月至2003年10月：克利夫兰医学中心Lerner研究所，博士后研究员
1996年4月至2000年4月，日本山梨医科大学，研究生
1995年1月至1996年3月，日本山梨医科大学病理部外入研究员
1986年9月至1989年6月，中国医科大学癌症研究所，研究生
出版物：
在乳腺/女性生殖系统研究期间发表：
Li X, Weaver O, Desouki M, Dabb D, Shyu S, Carter G, Zhao C. Microcalcification Is An Important Factor in the Management of Breast Introductal Papillomas Diagnosed on Core Biopsy. Am J Clin Pathol (submitted).
Li X, Desouki M, Dabbs D, Shyu S, Carter G, Wang L and Zhao C. Surgical excision may not be necessary for benign papillomas on core biopsy: a largest retrospective study in an academic women center. 2012 USCAP Annual Meeting
Li X, Kanbour-Shakir A, Dabbs D and Bhargava R. Predictors of Response to Trastuzumab Containing Neoadjuvant Chemotherapy in HER2 Positive Breast Cancers. 2012 USCAP Annual Meeting
Zhao C, Desouki, FloreaA, MohammedK, LiX, DabbsD (2011). Pathologic Findings of Follow-up Surgical Excision for Lobular Neoplasia on Breast Core Biopsy Performed for Calcification. Am J Clin Pathol. (accepted)
在AP/CP住院医师期间发表：
Li Z, Zhang Z, Xie J, Li X, Tian J, Cai T, Cui H, Di H, Shapiro J and Xie Z (2011) Na/K-ATPase Mimettic pNaKtide Peptide Inhibits the Growth of Human Cancer Cells. Journal of Biological Chemistry, 286 (37): 32394-32403
Muzaffar M, Chaudhary R, Li X, and Ratnam S(2011) Post-Transplant Plasma Cell Dyscrasia Presenting as Retroperitoneal Plasmacytoma: A Case Report and Literature Review. Dialysis & Transplantation, 130-132
Li X and Zyrek-Betts J (2010) Thyroid Malignancy Detected by Fine Needle Aspiration. Archives of Pathology & Laboratory Medicine Abstract for 2010 Annual Meeting of Collage of American Pathologists
Li X, Qi XP, Zhou LY, Fu W, Abdul-Karim F, MacLennan G, and Gorodeski GI (2009) P2X7 Receptor Expression Is Decreased in Epithelial Cancer Cells of Ectodermal Uro-genital Sinus, and Distal Paramesonephric-Duct Origin. Purinergic Signaling 5:351-368
During Research at Case Western Reserve University
Fu W, McCormick T, Qi X, Luo L, Zhou L, Li X, Wang BC, Gibbons HE, Abdul-Karim FW, and Gorodeski GI (2009) Activation of P2X7-Mediated Apoptosis Inhibits DMBA/TPA-induced Formation of Skin Papillomas and Cancer in Mice. BMC Cancer 20(9):114
Li X and Gohara A (2008) Melanoma and Unpredictable Metastases (abstract) 27th Annual Department pf Pathology, Dr. Peter Goldblatt Scientific Day Program
Li X, Qi X, Zhou L, Catera D, Rote NS, Potashkin J, Abdul-Karim FW, and Gorodeski GI (2007) Decreased Expression of P2X7 in Endometrial Epithelial Pre-Cancerous and Cancer Cells. Gynecol Oncol 106(1):233-243
Li X and Gorodeski G (2006) Non-muscle Myosin-II Heavy-chain-B Filament Regulation of Paracellular Resistance in Cervical Epithelial Cells is Associated with Modulation of the Cortical Acto-Myosin. Journal of The Society For Gynecologic Investigation 13(8):579-91
Li X and Gorodeski G (2006) Apically Sorted P2X7 Receptors Mediate Purinergic-induced Pore Formation Preferentially in Apical Domains of the Plasma Membrane. Nucleosides Nucleotides Nucleic Acid 25(9-11):1045-9
Feng YH, Li X, Zeng R, and Gorodeski GI (2006) Endogenously Expressed Truncated P2X7 Receptor Lacking the C-terminal is Preferentially Upregulated in Epithelial Cancer Cells and Fails to Mediate Ligand-induced Pore Formation and Apoptosis. Nucleosides Nucleotides Nucleic Acid 25(9-11):1271-6
Li X, Zhou LY, Feng YH, Abdul-Karim F, Gorodesk G (2006) The P2X7 Receptor:A Novel Biomarker of Uterine Epithelial Cancers. Cancer Epidemiol, Biomarkers Prev 15(10):1906-13
Li X, Zhou LY, Gorodeski G (2006) Estrogen Regulates Epithelial Cell Deformability by Modulation of Cortical Acto-Myosin through Phosphorylation of Non-Muscle Myosin-II Heavy-Chain B Filaments. Endocrinology 147(11):5236-48
Feng YH, Li X (equal first author), Wang L, Zhou L, and Gorodeski G (2006) A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization. J Biol Chem 281(25):17228-37
Zhu L, Li X, Zeng R, and Gorodeski G (2006) Changes in Tight Junction Resistance of the Cervical Epithelium Are Associated with Modulation of Content and Phosphorylation of Occludin 65-kilodalton and 50-kilodalton Forms. Endocrinology 147(2):977-89
Feng YH, Wang L, Wang Q, Li X, Zeng R, and Gorodeski G  (2005) ATP Stimulates GRK-3 Phosphorylation and Beta-arrestin-2-dependent Internalization of P2X7 Receptor. Am J Physiol 288(6):C1342-56
Wang Q, Li X, Wang L, Feng YH, Zeng R, and Gorodeski G (2004) Antiapoptotic Effects of Estrogen in Normal and Cancer Human Cervical Epithelial Cells. Endocrinology 145(12):5568-79
Zeng R, Li X, and Gorodeski G (2004) Estrogen Abrogates Transcervical Tight Junctional Resistance by Acceleration of Occludin Modulation. J Clin Endocrinol Metab 89(10):5145-55
Wang Q, Wang L, Feng YH, Li X, Zeng R, and Gorodeski G (2004) P2X7 Receptor-mediated Apoptosis of Human Cervical Epithelial Cells. Am J Physiol 287(5):C1349-58
在美国克利夫兰医疗中心Lerner研究所期间发表：
Kreitzer G, Schmoranzer J, Low SH, Li X, Gan Y, Weimbs T, Simon SM, and Rodriguez-Boulan E (2003) Three-dimensional Analysis of Post-Golgi Carrier Exocytosis in Epithelial Cells. Nature Cell Biology 5:126-136
Low S, Li X, Miura M, Kudo N, Quinones B and Weimbs T (2003) Syntaxin 2 and Endobrevin are Required Terminal Step of Cytokinesis. Developmental Cell 4:753-759
Weimbs T, Low SH and Li X and Kreitzer G (2003) SNAREs and Epithelial Cells. Methods 30:191-197
Li X, Low SH, Miura M, and Weimbs T (2002) Differential SNARE Expression and Localization in Renal Epithelial Cells Suggests Mechanism for Establishment of Distinct Trafficking Phenotypes. Am J Physiol 283:F1111-1122
Low, SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, and Weimbs T (2002) Retinal Pigment Epithelial Cells Exhibit Unique Expression and Localization of Plasma Membrane Syntaxins which may Contribute to Their Trafficking Phenotype. Journal of Cell Science 115:4545-4553
在日本山梨医科大学攻读博士期间发表：
Satoh Y*, Li X* (equal first author), Yokota H, Osada M, Ozaki Y, Katoh R, and Yatomi Y (2009) Regulation by Sphingolipids of the Fate of FRTL-5 Cells. Journal of Biochemistry 145(1):31-36
Miyagi E, Katoh R, Li X, Lu S, Suzuki K, Maeda S, Shibuya M, and Kawaoi A (2001) Thyroid Stimulating Hormone (TSH) Downregulates Vascular Endothelial Growth Factor Expression in FRTL-5. Thyroid 11:539-543
Lu S, Huang M, Kobayashi Y, Komiyama A, Li X, Katoh R, and Kawaoi A (2000) Alterations of Basement Membrane in Di-isopropanolnitrosamine-induced Carcinogenesis of the Rat Thyroid Gland: An Immunohistochemical Study. Virchows Arch 436:595-601
Katoh R, Kawaoi A, Miyagi E, Li X, Suzuki K, Nakamura Y and Kakudo (2000) Thyroid Transcription Factor-1 (TTF-1) in Normal, Hyperplastic, and Neoplastic Follicular Thyroid Cells Examined by Immunohistochemistry and Nonradioactive in Situ Hybridization. Modern Pathology 13(5):570-576
Katoh R, Miyagi E, Nokamura N, Li X, Suzuki K, Kakuda K, Kobayashi M and Kawaoi A (2000) Expression of Thyroid Trascription Factor-1(TTF-1) in Human C Cells and Medullary Thyroid Carcinomas. Human Pathology 31:386-393
Li X, Lu S, Miyagi E, Katoh R and Kawaoi (1999) Thyrotropin Prevents Apoptosis by Promoting Cell Adhesion and Cell Cycle Progression in FRTL-5 Cells. Endocrinology 140:5962-5970
Kawaoi A and Li X (1997) Immunocytochemistry of Cultured Cells (Japanese). In: Interdisciplinary Planning, Japanese Society of Histochemistry and Cytochemistry(ed) : pp90-98
Kawaoi A and Li X (1995) Detection of Apoptosis by In Situ Nick Translation (Japanese) In: Interdisciplinary Planning, Japanese Society of Histochemistry and Cytochemistry (ed): pp171-177
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