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徐波

 

Bo Xu, M.D., Ph.D.
 
Staff Physician and Assistant Professor of Oncology
Department of Pathology and Laboratory of Medicine
Roswell Park Cancer Institute
Elm and Carlton Streets, Buffalo, NY 14263
Phone: 716-845-5981 (Work); Fax: 716-845-3427; E-mail: bo.xu@roswellpark.org
 
 
EDUCATION:        
 
            M.D.                            1985 Nanjing Medical University Faculty of Medicine, Nanjing, China
            Ph.D.                           1996 Wright State University Biomedical Science Ph. D. Program, Dayton, OH
 
CERTIFICATION:
 
2010                Diplomat, The American Board of Pathology (ABP) in Combined Anatomic Pathology and Clinical Pathology, Certification Number:10-453
 
2006                Diplomat, Educational Commission for Foreign Medical Graduates (ECFMG/USMLE), Certificate Number: 06760219
 
MEDICAL LICENSURE:
 
                        2010                New York State Medical License, License Number: 257735
 
 
PROFESSIONAL EXPERIENCE:  
 
07/2011 --- Current     Staff Physician and Assistant Professor of Oncology, Roswell Park Cancer Institute, Buffalo, NY
 
07/2010 --- 06/2011    Clinical Fellow, Ontological Surgical Pathology, Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY
(06/01 - 06/30/2011)   Visiting Fellow, Section of Genitourinary Pathology, Indiana University School of Medicine, Indianapolis, IN
 
07/2009 --- 06/2010    Chief Resident, Department of Pathology, SUNY at Buffalo, Buffalo, NY
 
                        07/2006 --- 06/2009 Resident, Department of Pathology, SUNY at Buffalo,Buffalo, NY
                                                                       
                        10/2002 --- 10/2005   Project Staff (Research Assistant Professor Level)
                                                           Department of Clinical Pathology
                                                           The Cleveland Clinic Foundation
                                                           Cleveland, OH
 
09/2000 --- 09/2002    Staff Research Associate (Instructor Level)
Department of Cell Biology
The Cleveland Clinic Foundation
Cleveland, OH
 
07/1997 --- 08/2000    Research Associate
Department of Microbiology & Immunology
            Wright State University School of Medicine
Dayton, OH
 
09/1996 --- 06/1997    Post-doctoral Fellow
Howard Hughes Medical Institute
Department of Microbiology & Immunology
Vanderbilt University School of Medicine 
Nashville, TN
                                          
01/1988 --- 08/1990    Resident
Department of Medicine, Section of Neurology
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
                       
07/1984 --- 06/1985     Internship
             The First People's Hospital, Changzhou, China
 
 
ACADEMIC ACTIVITIES：
             TEACHING:          Teaching Pathology for medical students, residents and fellows of Medical and Dental Schools, SUNY at Buffalo, 2007-2012
                                            Teaching Assistant for Medical Physiology, Wright State University, School of Medicine, 1995
                                            Teaching Assistant for Cell Biology and Genetics, Wright State University, Graduate School, 1994
 
             MEMBERSHIPS:         United States and Canadian Academy of Pathology, 2003-present
                                               American Society of Clinical Pathologists, 2006-present
                                               College of American Pathologists, 2006-present
                                               American Society for Investigative Pathology, 2000-2005
                                               Association of Molecular Pathology, 2002-2005
                                               American Association for the Advancement of Science,1994-2000
  
AWARD/GRANT:
 
1. The Adrian O. Vladutiu Award for Excellence. The Department of Pathology & Anatomical Sciences, SUNY at Buffalo, June 2010.
 
2. Accomplishment Award presented by Commissioner of Health, County of Erie, NY, July 2010.
 
3. Neal S. Rote, Ph.D. and Bo Xu, M.D., Ph.D (Co-PI). The biological function of human endogenous retrovirus ERV-3 env in human placental trophoblast b-hCG production. $50,000. June 1, 1999 – May 31, 2000.
Kettering Foundation, Wright State University School of Medicine.
 
                             4. Bo Xu, M.D., Ph.D. The cellular mechanism of phosphatidylserine externalization in human trophoblast differentiation and apoptosis. $500. 2000. Young Investigator Award. International Federation of Placenta Associations.
 
 
VISA STATUS:     U.S. Citizen
 
 
PUBLICATIONS:
 
1. Liu, YG, Xu, B and Chen F. recent advances in renal cell carcinoma associated with Xp11.2 translocations/TFE gene fusions (Review article). 2012. North Am J Med & Sci. 5 (1):43-47. 
 
2. Hsi, LC, Kundu, S, Palomo J., Xu, B, Ficco, R, Vogelbaum, MA and Cathcart, MK. Silencing IL-13Ra2 promotes glioblastoma cell death via endogenous signaling. 2011. Mol Cancer Ther. 10(7):1149-60.
 
3. Xu, B., Tan, DF, Thong, T and Khoury, T. Expression of thyroid transcription factor-1 in Colorectal Carcinoma. 2010. Appl Immunohistochem Mol Morphol. 18(3):244-249.
 
4. Xu, B., Lin, L, and Chen, F.  Desmoplastic Trichoepithelioma with Milia-like Structure. 2009.  North Am J Med & Sci. 2 (1):22-23.
 
5. Xu, B., Balos, L., Goodloe, S., Krabill, K., Chmiel, R and Chen., F.  Immunohistochemical studies of cell cycle-associated proteins in mandible central giant cell tumor. 2009. North Am J Med & Sci. 2 (2):10-12. 
 
6. Skacel, M., Siva, A., Xu, B and Tubbs, RR. From array to array: Confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays. 2006. J Mol Histol. 38 (2):135-140.
 
7.Xu, B., Tubbs, RR and Kottke-Marchant, K. Molecular genetic testing of polymorphisms associated with venous thrombosis: A review of molecular technologies (Review Article). 2005. Diagn Mol Pathol. 14 (4):193-202.
 
8. Lin.L., Hicks, D., Xu, B., Sigel, JE., Bergfeld, WF., Montgomery, E., Fisher, C., Hartke, M., Tubbs, RR., Goldblum. JR. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. 2005. Modern Pathol. 18:705-709.
 
9. Zhao, X., Xu, B., Bhattacharjee, A., Horton, HM., Wientjes, FB., Cathcart, MK.
 
Protein kinase C-delta regulates p67phox phosphorylation in human monocytes. 2005. J Leukoc Biol. 77:414-420.
 
10. Xu, B., Bhattacharjee, A., Roy, B., Feldman, GM., Cathcart, MK., Role of protein kinase C isoforms in the regulation of IL-13-induced 15-lipoxygenase gene. 2004. J Bio Chem. 279 (16):15954-15960.
 
11. Bey, EA., Xu, B., Horton, CM., Bhattacharjee, A., Zhao, XX., Cathcart, MK. Protein kinase C-delta isoform mediates phosphorylation and membrane translocation of p47phox of NADPH oxidase in human monocytes. 2004. J Immunol. 173:5730-5738.
 
12.  Das, M., Xu, B., Lin, L., Chakrabarti, S., Shivaswamy, V., Rote, NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. 2004. Placenta. 25(5):396-407.
 
13. Xu, B., Bhattacharjee, A., Roy B., Xu, HM., Anthony D., Frank, DA., Feldman, GM., Cathcart, MK. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated Serine 727 phosphorylation of Stat1 and Stat3. 2003.
Mol Cell Biol. 23:3918-3928.
 
14. Zhang, YM., Xu, B., Rote, NS., Peterson, L., and Amesse, L. Expression and function of HOX genes in human trophoblastic cells. 2002. Am J Obstet Gynecol. 187:24-32.
 
15. Roy, B., Bhattacharjee, A., Xu, B., Ford, D., Maizel, AL and Cathcart, MK. IL-13 signal transduction in human monocytes: Phosphorylation of receptor components, association with Jaks and phosphorylation of Stats. 2002. J Leukoc Biol.72:580-589.
 
16. Lin, L., Xu, B., and Rote, NS. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in human placental trophoblast model, BeWo. 2000. Placenta. 21:73-78.
 
17. Xu, B., Lin, L. and Rote, NS. Identification of a novel stress-induced protein involved in human choriocarcinoma BeWo cell differentiation by differential display analysis. 1999. Biol Reprod.  61:681-686.
 
18. Lin, L., Xu, B., and Rote, NS. Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. 1999. Placenta. 20: 109-118.
 
19. Rote, N.S., Lin, L and Xu, B. The expression of ERV‑3 mRNA in a choriocarcinoma model of trophoblastic differentiation. In: Carter, A. and H. Thiede (ed.), New Directions in Placental Research. University of Rochester Press, Rochester, NY, 1998. Trophoblast Research. 12: 315-326.
 
20. Wang, L., Xu, B., White, RE and Lu, L. Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation. 1997. Am J Physiol. 273: C1657-1665
 
21. Xu, B., Wilson, B., Lu, L. Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. 1996. Am J Physiol. 271: C2037-C2044.
 
22. Xu, B., Lu, L. Protein kinase A-regulated Cl- channel in ML-1 human hematopoietic myeloblasts. 1994. J Membrane Biol. 142: 65-75.
 
 
PRESENTATIONS:
 
1. Xu, B., Cheney, RT., Omilian, AR., Liu Y., Morrison, C. March 2012. Expression of PAX2 and Renal Cell Carcinoma Antigen in Mucoepidermoid Carcinoma. The 101st Annual Meeting of United States and Canadian Academy of Pathology. Vancouver, BC, Canada.
 
 
2. Zhong, H., Azabdaftari, G and Xu, B. March 2012. Histopathological and Clinical Characterization of Intradiverticular Carcinoma in Urinary Bladder. The 101st Annual Meeting of United States and Canadian Academy of Pathology. Vancouver, BC, Canada.
 
 
3. Zhong, H, Omilian, AR., Morrison, C and Xu, B. March 2012. Activation of C-Jun N-Terminal Kinase Is Associated with Histological Grade of Mucoepidermoid Carcinoma. The 101st Annual Meeting of United States and Canadian Academy of Pathology. Vancouver, BC, Canada.
 
4. Xu, B., Guo, RJ., Balos, L., Woytash, JJ and Vertes, DR.  March 2010. Comparison of Autopsy Findings of 2009 Pandemic Influenza A (H1N1) with Seasonal Influenza in Pediatric Patients.  Accepted to present at Stowell-Orbison Surgical Pathology and Autopsy Award Poster Session at the 99th Annual Meeting of United States and Canadian Academy of Pathology, Washington, D.C.
 
5. Xu. B., Thong, T., Tan DF and Khoury, Y., October 2009. Positive immunoreactivity of thyroid transcription factor-1 (TTF-1) in colorectal carcinoma: a tissue microarray study of 104 cases. The annual meeting of College of American Pathologists, Washington, D.C.
 
6. Xu, B., Lin, L and Chen, F. October 2008. Desmoplastic trichoepithelioma with milia-like structure. The 45th annual meeting of American Society of Dermatolopathologists, San Francisco, CA.
 
7. Xu, B., Balos, L., Goodloe, S., Krabill, K., Chmiel, R., Chen, F. October 2007. Immunohistochemical studies of cell cycle-associated proteins in mandible central giant cell tumor. The annual meeting of College of American Pathologists, Chicago, IL.
 
8. Xu, B., Pettay, JD., Skacel, M., Prayson, RA., Barnett, GH., Tubbs, RR. March 2005. Differential amplification and expression of CDK6 between low-grade astrocytoma and glioblastoma multiforme. The 94th Annual Meeting of United States and Canadian Academy of Pathology. San Antonio, TX.
 
9. Xu, B., Thompson, S., Perez, V., Koenigsberger., C, Pettay., J, Silbergleit., A, Kawashima., T, Yang., X, Marchant., K and Tubbs, R. November 2004. Clinical Validation of Genetic Polymorphisms Associated with Venous Thromboembolism by the GeneOhm ePlex™ Electrochemical Array. The 11th Annual Meeting of Association for Molecular Pathology, Los Angeles, CA. 
 
10. Xu, B., Pettay, JD., Skacel, M., Hartke, M., Prayson, RA., Barnett, GH., Tubbs, RR. March 2004. Distinctive genetic aberrations of low-grade and high-grade gliomas defined by array-based comparative genomic hybridization. The 93th Annual Meeting of United States and Canadian Academy of Pathology. Vancouver, BC, Canada.
 
11. Xu. B., Tubbs, RR., Barnett, GH., Prayson, RA. June 2004. Array-based Comparative Genomic Hybridization in Cortical Dysplasia and Gangliogliomas. The 80th Annual Meeting of the American Association of Neuropathologists. Cleveland, OH.
 
12. Xu, B., Bhattacharjee, A., Roy B., Xu, HM., Anthony D., Frank, DA., Feldman, GM., Cathcart, MK., 2003. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated Serine 727 phosphorylation of Stat1 and Stat3. Annual Meeting of American Society for Investigative Pathology, San Diego, CA.
 
13. Xu, B., Cathcart, MK, Transcriptional Regulation of 15-Lipoxygenase Gene Expression in Human Monocytes., 2001. Keystone Symposia: Cellular and Molecular Events in the Pathogenesis of Atherosclerosis. Keystone, CO.
 
14. Xu, B., Lin, L. Huang, K., Zhang YM., Amesse, L., and Rote, NS., 2000. Expression and function of a novel stress-induced protein, RTP, in human trophoblastic cells. The 47th Annual Meeting of the Society for Gynecologic Investigation. Chicago, IL.
 
15.Xu, B., Lin, L. and Rote, NS., 1998. Identification of novel genes involved in BeWo cell differentiation. The 4th Conference of the International Federation of Placental Associations. Tokyo, Japan. 
 
16. Xu, B., Wilson, B., Lu, L., 1995. Functional role of retinoblastoma protein in phorbol ester induced terminal differentiation of hematopoietic myeloblasts. The 37th American Hematology Society Annual Meeting. Seattle, WA. 
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