何妙侠，女，长海医院病理科副主任医师，副教授，硕士生导师，科室副主任。

毕业于四川大学华西临床医学院，从师李甘地、刘卫平教授，获病理学博士学位。2015年至2016年赴美国国家卫生院(NIH)访学进修一年，从师国际著名的淋巴瘤病理专家Elaine Jaffe教授和软组织肿瘤病理专家Markku Miettinen教授。中国抗癌协会淋巴瘤专业委员会委员，上海市抗癌协会淋巴瘤专业委员会委员。

医学专长

专长临床各种常见病、疑难病，尤其是淋巴造血组织肿瘤和骨髓活检的的病理诊断与鉴别诊断。在淋巴瘤的规范化诊断与病理分类方面具有丰富的诊断与鉴别诊断经验，并能积极引入分子病理新技术辅助淋巴组织疾病的诊断。

医研教成果

积极从事医疗、科研与教学工作。医疗方面：完成大量临床医疗工作，多次被评为院优秀医疗工作者。科研方面：主持国家自然科学基金面上项目1项，参与面上项目2项，参与完成青年项目1项，面上项目2项；获国家发明专利1项，实用新型专利1项；参编淋巴瘤相关专著2部；发表科研论文近60篇，其中SCI收录20余篇，单篇最高影响因子7.371分。教学方面：发表教学论文10余篇，其中SCI收录1篇；完成第二军医大学教改课题面上项目2项，获校教改课题成果奖2项，中华医学会教育学分会优秀教学论文奖1项；荣获院优秀带教教员，院优秀教案二等奖，被评为第二军医大学最受学员喜爱的老师。医研教工作成绩突出，被评为院及校优秀文职人员，并荣立三等功2次。

近年来发表的相关论文

(1) He M, Chen K, Li S, Zhang S, Zheng J, Hu X, Gao L, Chen J, Song X, Zhang W, Wang J, Yang J.Clinical Significance of "Double-hit" and "Double-protein" expression in Primary Gastric B-cell Lymphomas.J Cancer. 27(10):1215-1225.2016.(SCI IF 3.609) 

(2) Chen Y, Yang S, Hu J, Yu C, He M*, Cai Z. Increased Expression of SETD7 Promotes Cell Proliferation by Regulating Cell Cycle and Indicates Poor Prognosis in Hepatocellular Carcinoma. PLoS One. 11(5):e0154939.2016. (SCI IF 3.057)

(3) Su Y, Sun B, Lin X, Zhao X, Ji W, He M, Qian H, Song X, Yang J, Wang J, Chen J. Oncotarget. Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma. 7(31):49143-49155. 2016. (SCI IF 5.008)

(4) Yang K, He M#, Cai Z, Ni C, Deng J, Ta N, Xu J, Zheng J. A decrease in miR-150 regulates the malignancy of pancreatic cancer by targeting c-Myb and MUC4. Pancreas. 44(3):370-379. 2015.(SCI IF 3.008)

(5)He M, Gao L, Zhang S, Tao L, Wang J, Yang J, Zhu M. Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL. Gastric Cancer.17(3):431-441. 2014. (SCI IF 4.896)

(6) Shi H, Han Y, He M, Huang L, Bai C, Li Q, Ma D. Primary tracheobronchial anaplastic large cell lymphoma in an 8-year-old child presenting with asthma-like symptoms. Chin Med J (Engl). 127(4):794-795. 2014.(SCI IF 0.957)

(7) Deng J, He M#, Chen L, Chen C, Zheng J, Cai Z. The loss of miR-26a-mediated post-transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival. PLoS One. 8(10):e76450.2013. (SCI IF 3.057)

(8) He M, Zuo C, Wang J, Liu J, Jiao B, Zheng J, Cai Z. Prognostic significance of the aggregative perivascular growth pattern of tumor cells in primary central nervous system diffuse large B-cell lymphoma.Neuro Oncol. 15(6):727-34. 2013.(SCI IF 7.371)

(9) Sun J, Yang Q, Lu Z, He M, Gao L, Zhu M, Sun L, Wei L, Li M, Liu C, Zheng J, Liu W, Li G, Chen J. Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol. 138(3):429-434.2012. (SCI IF 2.598)

(10) S Zhao, QL Tang, MX He, F Yang, H Wang, WY Zhang, W Jiang, XL Wang, XM Mo, GD Li and WP Liu. A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma. Leukemia. 22(1): 170-178, 2008. (SCI IF 8.296)

(11) MX He, LL Wu, MH Zhu, CG Bai, SM Zhang, JJ Wang. Primary Cutaneous MZL with Amyloid Deposition, Initially Misdiagnosed as Amyloidosis Mimics Primary Dural MZL upon Dural Dissemination.O J Pathology.3, 21-25.2013.

(12) Li J, Zhang Y, Lou J, Zhu J, He M, Deng X, Cai Z. Neutralisation of peritoneal IL-17A markedly improves the prognosis of severe septic mice by decreasing neutrophil infiltration and proinflammatory cytokines. PLoS One. 7(10):e46506, 2012. (SCI IF 4.092)

(13) He MX, Wang JJ. Rhabdoid glioblastoma: Case report and literature review. Neuropathology. 31:421-426. 2011. (SCI IF 1.867)

(14)Wang D, Liu Y, Han J, Zai D, Ji M, Cheng W, Xu L, Yang L, He M, Ni J, Cai Z, Yu C.uerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. PLoS One. 6(9):e25011, 2011. (SCI IF 4.092)

(15) He MX, Wang JJ. Zhu Z, Wang Y, Li L, Zhang P, Zheng JM. A survey study of military medical students to autopsy in modern medical education. Scientific Research and Essays. 6(32): 6666-6670, 2011. (SCI IF 0.443)

(16) He MX, Zheng JM, Zhang SH, Wang JJ, Liu WQ, Zhu MH.Rupture of splenic artery aneurysm in pregnancy: a review of the literature and report of two cases.Am J Forensic Med Pathol. 31(1):92-94,2010. (SCI IF 0.713)

(17) He MX, Song B, Jiang H, Hu XG, Zhang YJ, Zheng JM.Complete resection of isolated pancreatic metastatic melanoma: a case report and review of the literature.World J Gastroenterol. 16(36):4621-4624, 2010. (SCI IF 2.092)

(18) Ying M, Li D, Yang L, Wang M, Wang N, Chen Y, He M, Wang Y. Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma.J Cancer Res Clin Oncol. 136(10): 1617-1626, 2010 (SCI IF 2.485)