中山大学肿瘤防治中心病理科主任，教授/主任医师，博士生导师。

学习简历：

1980.09-1985.06  湖南医科大学，临床医学本科

1988.09-1991.06  中山医科大学病理教研室，硕士

1997.01-1991.07  香港中文大学病理学系，外科病理进修

1998.03-2001.03  香港中文大学病理学系，博士

工作简历：

1985.07-1988.08   湖南医科大学病理教研室 助教

1991.07-1998.03  中山大学肿瘤防治中心病理科 医师和主治医师

2001.03-至今  中山大学肿瘤防治中心病理科 主治医师、副教授及教授/主任医师

2010.10-至今 中山大学肿瘤防治中心病理科 副主任及主任

临床工作：

专长于肿瘤临床病理诊断，偏向于肝肿瘤病理。

研究工作：

近十年内先后主持了五项国家自然基金项目，发表SCI文章50余篇，其中以第一作者及通讯作者发表论文18篇，包括Oncogene,Carcinogenesis,Cell cycle等知名杂志。作为华南国家重点实验室的PI,近年来主要从事三方面研究，一是研究细胞增殖蛋白Nucleophosmin/B23在人体肿瘤发生发展中的作用和意义及其参与细胞周期和增殖的机制；二是研究miRNA在肿瘤发生发展中的作用和机制；第三，开展肿瘤病理分子分型的相关研究。

社会兼职：

担任三本专业杂志编委：《癌症》、《中华肿瘤防治杂志》、《肿瘤防治研究》

中国医师协会广东省医师病理分会副主任委员

广东省医学会病理专业委员会常务委员

广东省抗癌协会小儿肿瘤专业委员会常务委员

近年发表的部分研究论文（*为通讯作者）：

1: Li LZ, Zhang CZ, Liu LL, Yi C, Lu SX, Zhou X, Zhang ZJ, Peng YH, Yang YZ, Yun

JP*. miR-720 inhibits tumor invasion and migration in breast cancer by targeting

TWIST1. Carcinogenesis. 2013 Nov 1. [Epub ahead of print] PubMed PMID: 24085799.

2: Huang Y, Li LZ, Zhang CZ, Yi C, Liu LL, Zhou X, Xie GB, Cai MY, Li Y, Yun JP*.

Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma

associates with poor prognosis. J Transl Med. 2012 May 24;10:106.

3: Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP*. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. Oncogene. 2012 Jan 16. doi: 10.1038/onc.2011.629.

4: Liu L, Zhang CZ, Cai M, Fu J, Chen GG, Yun J*. Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. PLoS One. 2012;7(7): Epub 2012 Jul 19.

5. Zhang CZ, Liu L, Cai M, Pan Y, Fu J, Cao Y, Yun J*. Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One. 2012;7(12): Epub 2012 Dec 14.

6: Zhang CZ, Pan Y, Cao Y, Lai PB, Liu L, Chen GG, Yun J*. Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo. PLoS One. 2012;7(6): Epub 2012 Jun 28.

7.Tang Z, Yuan S, Hu Y, Zhang H, Wu W, Zeng Z, Yang J, Yun J, Xu R, Huang P*. Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-Bromopyruvate Propyl Ester. J Bioenerg Biomembr. 2012 Feb 18. [Epub ahead of print]

8.Cai MY, Luo RZ, Chen JW, Pei XQ, Lu JB, Hou JH, Yun JP*. Overexpression of ZEB2

in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular Carcinoma. PLoS One. 2012;7(2):e32838. Epub 2012 Feb 29.

9.Wang X, Liang Y, Chen Q, Xu HM, Ge N, Luo RZ, Shao JY, He Z, Zeng YX, Kang T, Yun JP*, Xie F*. Prognostic significance of SOX2 expression in nasopharyngeal carcinoma. Cancer Invest. 2012 Jan;30(1):79-85.

10.Wang QQ, Zhang ZY, Xiao JY, Yi C, Li LZ, Huang Y, Yun JP*. Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells. Chin J Cancer. 2011 Dec;30(12):853-60.

11.Li JD, Zhuang Y, Li YF, Feng YL, Hou JH, Chen L, Zhu AN, Wu QL, Yun JP*. A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. J Clin Pathol. 2011 Dec;64(12):1102-7.

12.Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, Chen JG, Chen YB, Yun JP*, Xia JC*. The accumulation and prognosis value of tumor infiltrating IL-17 producing cells  in esophageal squamous cell carcinoma. PLoS One. 2011 Mar 31;6(3):e18219.

13.Huang L, Zheng M, Zhou QM, Zhang MY, Jia WH, Yun JP, Wang HY*. Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma. Cancer. 2011 Aug 1;117(15):3363-73.

14.Xu S, Feng Z, Zhang M, Wu Y, Sang Y, Xu H, Lv X, Hu K, Cao J, Zhang R, Chen L, Liu M, Yun JP, Zeng YX, Kang T*. hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas. Oncogene. 2011 May 12;30(19):2219-29.

15.Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM*. Effects of

microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular

carcinoma. Hepatology. 2010 Mar;51(3):836-45.

16.Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM*. MicroRNA-195 suppresses

tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma

cells. Hepatology. 2009 Jul;50(1):113-21.

17.Xiao J, Zhang Z, Gong Chen G, Zhang M, Ding Y, Fu J, Li M, Yun JP*. Nucleophosmin/B23 interacts with p21(WAF1/CIP1) and contributes to its stability. Cell Cycle. 2009 Mar 21;8(6). 889-95.

18.Zhang MF, Zhang ZY, Fu J, Yang YF, Yun JP*. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med. 2009 Dec 22;7:110.

19.Kuang DM, Zhao Q, Xu J, Yun JP, Wu C, Zheng L*. Tumor-educated tolerogenic dendritic cells induce CD3epsilon down-regulation and apoptosis of T cells through oxygen-dependent pathways. J Immunol. 2008 Sep 1;181(5):3089-98.

20.Miao J, Chen GG*, Yun JP, Chun SY, Zheng ZZ, Ho RL, Chak EC, Xia NS, Lai PB.  Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. Apoptosis. 2007 Sep;12(9):1691-701.

21.Yun JP*, Zhang MF, Hou JH, Tian QH, Fu J, Liang XM, Wu QL, Rong TH. Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases. BMC Cancer. 2007 Mar 3;7:38.

22.Yun JP*, Miao J, Chen GG, Tian QH, Zhang CQ, Xiang J, Fu J, Lai PB. Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters. Br J Cancer. 2007 Feb 12;96(3):477-84.

23.Yun JP*, Liew CT, Chew EC, et al.  Nuclear matrix protein expressions in hepatocytes of normal and cirrhotic rat livers under normal and regenerating conditions. J Cell Biochem. 2004;91(6):1269-79.

24.Yun JP*, Chew EC, Liew CT, et al. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix.J Cell Biochem. 2003;90(6):1140-8.