沈四九

 

现在美国Cornell大学Weill医学院Methodist医院病理系做病理医生,该院研究所助理成员,病理学与实验医学副教授;
全美华人病理学会(CAPA)的成员,一直致力于推动中美诊断病理学的教育和合作项目;
主要研究领域:泌尿生殖病理学及膀胱病理学的一些诊断问题。

教育与培训经历
1979-1984湖北武汉同济医科大学 本科
1984-1987湖北武汉同济医科大学 硕士
1989-1994美国Texas大学Houston健康科学中心 生物化学和分子生物学 博士
1994-1995美国Texas大学Houston医学院 生物化学和分子生物学 博士后
1995-1997美国NIH(国立卫生院) 研究学者
1997-2001美国Pennsylvania州立大学/Hershey医学中心 解剖与临床病理学的住院医师
2001-2002美国Texas大学Anderson博士肿瘤中心 外科病理学研究员
2002-2003 Baylor医学院助理教授
2004-  Methodist医院病理系
2008-  康奈尔大学威尔医学院病理系副教授

Steven S. Shen(沈四九), MD, PhD
Staff pathologist, Department of Pathology, The Methodist Hospital
Assistant Member, The Methodist Hospital Research Institute
Associate Professor of Pathology and Laboratory Medicine,
Weill Medical College of Cornell University
 
The Methodist Hospital
Department of Pathology M227
6565 Fannin Street
Houston, Texas 77030
Phone: 713.441.6987
Fax: 713-793-1603
Email: stevenshen@tmhs.org
 
Education and Training
1979-1984         M.D., Tongji Medical University, Wuhan, Hubei, P. R. China
1984-1987         M.S., Tongji Medical University, Wuhan, Hubei, P. R. China
1989-1994         Ph.D., Biochemstry and Molecular Biology, The University of Texas Houston Health Science Center, Houston, Texas
1994-1995         Postdoctoral Fellow, Biochemstry and Molecular Biology, The University of Texas Houston Medical School, Houston, Texas
1995-1997         Research Fellow, National Institutes of Health, Bethesda, Maryland
1997-2001         Anatomical and Clinical Pathology Residency, Penn State University/Hershey Medical Center, Hershey, Pennsylvania
2001-2002         Surgical Pathology Fellow, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
 
Biography
Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology at the Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is an Assistant Member of TMHRI. He has served as a section editor of Archive of Pathology and Laboratory Medicine Since 2005 and a reviewer for several journals in pathology and urology. He was one of the co-chairs of Academic Committee for the past two years and currently the Secretary and Executive Committee member of Chinese American Pathologist Association (CAPA).  He is passionate about promotion of educational and collaborative programs in diagnostic pathology between the United State and China.
 
Description of Research
Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and their correlation with diagnosis, prognostication and treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, testis, and prostate.
 
Major Areas of Research
Genitourinary pathology, renal cell carcinoma, urothelial carcinoma, prostate cancer, tumor metastases
 
Recent Publications
1.      Shen SS, Haupt BX, Ro, JY, Zhu J, Bailey HR, and Schwartz MR. Numbers of lymph nodes examined and associated clinicopathologic factors in colorectal carcinoma. Arch Pathol Lab Med 2008 (accepted)
2.      Sonpavde G, Jian W, Liu H, Wu MF,  Shen SS, Lerner SP. Sunitinib malate is active as a single agent and in combination with cisplatin in a preclinical model of human urothelial carcinoma. Urologic Oncology 2008 (accepted)
3.      Lerner SP, Colen J, and Shen SS. Prostatic biology, histologic patterns and clinical consequences of transitional cell carcinoma. Current Opinion in Urology 2008 (in press)
4.      Jung SJ, Ro JY, Truong LD, Ayala AG, and Shen SS. Reappraisal of T3N0/NxM0 renal cell carcinoma: significance of extent of fat invasion, renal vein invasion, and adrenal invasion. Human Pathol. 2008 (in press)
5.      Goh AC, Tresser NJ, Shen SS, and Lerner LP. Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer. Urology 2008 (Accepted)
6.      Ro JY, Shen SS, Lee HI, Lee YH, Cho NH, Jung SJ, Choi YJ, and Ayala AG. Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of nine cases. Am J Surg Pathol 2008 32(5):752-757.
7.      Suh JH, Gardner JM, Kee KH, Shen SS, Ayala GA, and Ro JY. Calcifications in prostate and ejaculatory system: a study on 298 consecutive whole mount sections of prostate from radical prostatectomy or cystoprostatectomy specimen.  Ann Diag Pathol 2008 12(3):165-170.
8.      Shen SS*, Jung SJ*, Tran T,  Jun SY, Ayala AG, and Ro JY, Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature. Human Pathology 2008 39(3):463-8. (*denote equal contribution).
9.      Yang XJ, Zhou M, Hes O, Shen SS, Li R, Shah RB, Chuang ST, Lin F, Tretiakova MM, Knoll E, and Teh BT. Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol 2007 32(2):177-187.
10. Shen SS and Lerner, SP. Prostatic transitional cell carcinoma: pathologic features and clinical management. Expert Review of Anticancer Therapy 7(8):1155-1162.
11. Lerner SP and Shen SS. Pathologic assessment and clinical significance of prostatic involvement by transitional cell carcinoma and prostate cancer. Urology Oncology 2008 (in press).
12. Teh BS, Bloch C, Paulino AC, Shen SS, Hinckley L, Baskin D, Butler EB, Amato R. Pathologic complete response in renal cell carcinoma brain metastases treated with stereostatic radiosurgery. Clinical Genitourinary Cancer 2007 5:334-7.
13. Li L, Yao JL, di Sant’Agnese PA, Bourne PA. Picken MM, Young AN, Shen SS, and Huang J. Expression of claudin-7 in benign kidney and kidney tumors. International Journal of Clin and Exp Pathol 2008 (accepted).
14. Haupt B, Ro JY, Schwartz MR, Shen SS. Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis. Modern Pathol 2007 20: 729-733.
15. Sonpavde G, Okuno N, Weiss H, Yu J, Shen SS, Younes M, Jian W, Lerner SP, Smith CL:  Efficacy of selective estrogen receptor modulators (SERMS) in nude mice bearing human transitional cell carcinoma.  Urology 2007 69:1221-6.
16. Ozcan A, Shen SS, Zhai Q, and Truong LD. Expression of Glu1 in primary renal tumors: morphologic and biologic implication. Am J of Clin Pathol 2007 128:245-54.
17. Tang WW, Stelter, AA, French S, Shen SS, Qiu S, Venegas R, Wen J, Wang HQ, and Xie J. Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. Modern Pathol 2007 20:509-513.
18. Akgun H, Ozcan A, Chirala M, Zhai J, Shen SS, Suki WN, and Truong, LD. Lymphoid cell proliferation in renal transplants biologic and diagnostic implications.  Clinical Transplantation 2007 21:472-80.
19. Shen SS, Truong LD, Ayala AG, and Ro JY. Recently described and emphasized entities of renal neoplasms. Arch Pathol Lab Med 2007 131:1234-43.
20. Vakar-Lopez F, Shen SS, Zhang S, Tamboli P, Ayala AG, and Ro JY. Muscularis mucosae of urinary bladder revisited with emphasis on its hyperplastic patters: A study of a large series of cystectomy specimens.  Annals of Diagnostic Pathology 2007 11(6):395-401.
21. Shen SS, Ro JY, Tamboli P, Truong LD, Zhai Q, Jung SJ, Tibbs RG, Odornez N, Ayala AG. Mucinous tubular and spindle cell carcinoma of kidney: histologic and immunohistochemical features favoring proximal nephron differentiation.  Annals of Diagnostic Pathology 2007 11:13-21.
22. Lin F, Zhang PL,Yang XJ, Shi J, Blasick T, Han WK, Wang H, Shen SS, Teh BT, Joseph V Bonventre JV. Human Kidney Injury Molecule-1 (hKIM-1): A Useful Immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am J Surg Pathol 2007 31: 371-381.
23. Gonlusen G, Truong A, Shen SS, Androgue HE, Ramanathan V, and Truong LD. Granulomatous pyelonephritis associated with urinary obstruction: a comprehensive clinicopathologic study. Modern Pathol 2006 19:1130-1138.
24. Ziari M, Shen SS, Amato RJ, Teh BS. Metastatic renal cell carcinoma to the nose and ethmoid sinus. Urology 2006 67:199.
25. Shen SS, Smith CL, Hsieh JT,  Yu J, Kim IY, Jian W, Sonpavde G, Ayala G, Younes M, Lerner SP. Expression of estrogen receptor α and β in bladder cancer cell lines and human bladder tumor tissue. Cancer 2006 106:2610-6.
26. Shen SS, Lerner SP, Muezzinoglu B, Truong LD, Amiel G, and Wheeler TM. Prostatic involvement by transitional cell carcinoma in patients with bladder cancer and its prognostic significance. Human Pathol 2006 37:726-34.
27. Prieto VG, Mourad-Zeidan AA, Melnikova V, Johnson MM, Lopez A, Diwan AH, Lazar AJ, Shen SS, Zhang PS, Reed JA, Gershenwald JE, Raz A, and Bar-Eli M. Analysis of galectin-3 expression in melanocytic lesions by tissue array: possible involvement in tumor progression. Clin Cancer Res 2006 12:6709-15.

已举办讲座

我要评论

0条评论