UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE BIOGRAPHICAL

Name: Changqing Ma

Business Address: University of Pittsburgh, Department of Pathology 200 Lothrop Street, A-610 Pittsburgh, PA 15213

EDUCATION AND TRAINING

GRADUATE:

Sep. 1993 – Jun. 1998

Beijing Medical University Beijing, P.R. China

BM, 1998

Medicine

Sep. 1999 – Aug. 2005

University of Pittsburgh School of Medicine Pittsburgh, PA

PhD, 2005

Cellular and Molecular Pathology

POSTGRADUATE:

Sep. 2005 – Aug. 2006

University of Pittsburgh Cancer Institute Pittsburgh, PA

Postdoctoral Fellowship

Postdoctoral fellow

Sep. 2006 – May 2009

University of Pennsylvania School of Medicine Philadelphia, PA

Postdoctoral Fellowship

Postdoctoral fellow

Jul. 2009 – Jun. 2013

Washington University School of Medicine St. Louis, MO

Residency

Resident in Anatomic and Clinical Pathology

Jul. 2013 – Jun. 2014

Johns Hopkins University School of Medicine Baltimore, MD

Clinical Fellowship

Clinical Fellow in Gastrointestinal and Liver Pathology

APPOINTMENTS AND POSITIONS

ACADEMIC:

Jul. 2014 – Present

University of Pittsburgh Pittsburgh PA

Assistant Professor of Pathology

CERTIFICATION AND LICENSURE

SPECIALTY CERTIFICATION:

Certification ECFMG 2008

Certification in Anatomic Pathology and Clinical Pathology The American Board of Pathology 2013

MEDICAL OR OTHER PROFESSIONAL LICENSURE:

License Missouri State Board of Registration for the Healing Arts Physician and Surgeon 2013

License Pennsylvania State Board 2014

MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES

United States & Canadian Academy of Pathology 2009 -- Present

College of American Pathologist 2009 -- Present

PUBLICATIONS

Refereed articles:

1. Ying J, Jin Y, Wang H, Hou L, Ma C, and Zhang B. Molecular cloning of hTRT catalytic domain and its expression in tumors. Zhonghua Bing Li Xue Za Zhi 1999, 28(2):85-88. PMID: 11869512

2. Wei J, Zhang B, Yuan X, Ying J, Ma C, and Hou L. Expression of hTR in human tumors. Zhonghua Bing Li Xue Za Zhi 1999, 28(4): 290-291.

3. Chandran UR, Dhir R, Ma C, Becich MJ, and Gilbertson JR. Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ

donors. BMC Cancer 2005, 5:45. PMID:15892885

4. Ma C, Lyons-Weiler M, Liang W, Becich MJ, Gilbertson JR, and Monzon FA. In vitro transcription amplification and labeling methods contribute to the variability of gene expression profiling with DNA

microarrays. J Mol Diagn 2006, 8(2): 183-192. PMID:16645204

5. Chandran UR, Ma C, Dhir R, Bisceglia M, Lyons-Weiler M, Liang W, Michalopoulos G, Becich MJ, and Monzon FA. Gene expression profiles of prostate cancer reveal involvement of multiple molecular

pathways in the metastatic process. BMC Cancer 2007, 7:64. PMID:17430594

6. D'Antonio JM, Ma C, Monzon FA, and Pflug BR. Longitudinal analysis of androgen deprivation of prostate cancer cells identifies pathways to androgen independence. Prostate. 2008, 68(7):698-714. PMID:18302219

7. Nellore A, Paziana K, Ma C, Tsygankova OM, Wang Y, Puttaswamy K, Iqbal AU, Franks SR, Lv Y,Prendergast GV, Troxel AB, Feldman MD, Meinkoth JL, and Brose MS. Progressive loss of Rap1GAP

from benign nodules to invasive thyroid cancer. J Clin Endocrino Metab 2009, 94(3): 1026-1032.PMID:19066305

8. Ma C, Quesnelle KM, Sparano A, Rao S, Park MS, Cohen MA, Wang Y, Samanta M, Kumar MS, Aziz MU, Naylor TL, Weber B, Fakharzadeh SS, Weinstein GS, Vachani A, Feldman MD, and Brose MS. Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.Cancer Biol Ther 2009, 8(10): 907-916. PMID:19276661

9. Bass AJ, Watanabe H, (22 additional authors), Ma C, (22 additional authors), and Meyerson M. SOX2 isan amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009, 41(11):1238-1242. PMID:19801978

10. Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PJ, and Biegel JA. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol 2010,12(7):621-630. PMID:20156809

11. Tsygankova OM, Ma C, Tang W, Korch C, Feldman MD, Lv Y, Brose MS, and Meinkoth JL.Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol 2010, 30(13):3262-3274. PMID:20439492

12. Neely RJ, Brose MS, Gray CM, McCorkell KA, Leibowitz JM, Ma C, Rothstein JL, and May MJ. The RET/PTC3 oncogene activates classical NF-kappaB by stabilizing NIK. Oncogene 2011, 30(1):87-96.PMID:20818435

13. Porembka MR, Hawkins WG, Linehan DC, Gao F, Ma C, Brunt EM, and Strasberg SM. Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreas. HPB (Oxford) 2011, 13(9):633-642. PMID:21843264

14. Ma C, and Lewis J. Small biopsy specimens reliably indicate p16 expression status of oropharyngeal squamous cell carcinoma. Head Neck Pathol 2012, 6(2):208-215. PMID:22203477

15. Dehdashti F, Grigsby PW, Myerson RJ, Parikh PJ, Nalbantoglu I, Ma C, and Siegel BA. Positron emission tomography with [18F]-3'-deoxy-3'fluorothymidine (FLT) as a predictor of outcome in patients with locally advanced resectable rectal cancer: a pilot study. Mol Imaging Biol 2013, 15(1):106-113.PMID:22684813

16. Ma C, Crippin JS, Chapman WC, Korenblat K, Vachharajani N, Gunter KL, and Brunt EM. Vascular alterations in explant hepatectomies from patients with hepatopulmonary syndrome or portopulmonary hypertension. Liver Transpl. 2013, 19(7):741-750. PMID:23463612

17. Henke LE, Perkins SM, Pfeifer JD, Ma C, Chen Y, DeWees T, and Grigsby PW. BRAF V600E mutational status in pediatric thyroid cancer. Pediatr Blood Cancer. 2014, 61(7):1168-1172. PMID:24677749

18. Ma C, Montgomery EA, and Lam-Himlin D. Docetaxel therapy induced diffuse atypia and mitotic arrest mimicking dysplasia – a diagnostic pitfall. Diagnostic Histopathology 2014, 20, 46-47.

19. Ma C, Giardiello FM, and Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients:dysplasia and malignancy are often associated with foveolar, intestinal and pyloric differentiation. Am J Surg Pathol. 2014, 38(12):1618-1626. PMID: 25390638

20. Henke LE, Pfeifer JD, Ma C, Perkins SM, DeWees T, El-Mofty S, Moley JF, Nussenbaum B, Haughey BH, Baranski TJ, Schwarz JK, and Grigsby PW. BRAF mutation is not predictive of long-term outcome in papillary thyroid carcinoma. Cancer Med. 2015, 4(6):791-799. PMID: 25712893

21. Ma C, Park JY, Montgomery EA, Arnold CA, McDonald OG, Liu TC, Salaria SN, Limketkai BN, Mcgrath KM, Musahl T, and Singhi AD. A comparative clinicopathologic study of collagenous gastritis in children and adults: the same disorder with associated immune-mediated diseases. Am J Surg Pathol. 2015,39(6):802-812. PMID: 25871617

22. Ma C, Maluf H, and Liu TC. Acute gastrointestinal graft versus host disease is more common and severe in lower than upper tract. Accepted (Human Path)

23. Ma C, Gocke CD, Hruban RH, and Belchis DA. Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia. Accepted (Human Path)

24. Ma C and Brunt EM. Terminal hepatic venule injury in liver biopsies of allogeneic hematopoietic stem cell recipients - a study of 63 cases. Accepted (Histopathology)

25. Ma C, Chen CH, and Liu TC. The spectrum of gastric endoscopy and pathology in patients with portal hypertension – a study of 550 cases. Under review

Reviews and Book Chapters:

1. Ma C, Lewis J, and Chernock RC. Chapter 24: Thyroid. In Humphrey PA, Dehner LP, and Pfeifer JD,editors. The Washington Manual of Surgical Pathology, 2nd ed. Philadelphia, Pennsylvania: Lippincott Williams & Wilkins; 2012.

2. Ma C, and Brunt EM. Histopathologic evaluation of liver biopsy for cirrhosis. Adv Anat Pathol 2012,19(4):220-230. PMID:22692285

3. Ma C, and Gronoswski AM. Laboratory workup of well-differentiated pancreatic neuroendocrine tumors.Clinical Chem ASCP Case Reports series 2014; CC 14-3.

4. Ma C, Limketkai BN, and Montgomery EA. Recently highlighted non-neoplastic pathologic entities of the upper gastrointestinal tract and their clinical significance. Gastrointest Endosc. 2014, 80 (6):960-969.PMID:25434655

5. Ma C and Pai RK. Predictive value of immunohistochemistry in pre-malignant lesions of the gastrointestinal tract. Semin Diagn Pathol. 2015 Feb 4. pii: S0740-2570(15)00015-5. PMID: 25749205

Other publications:

Ma C, Gronoswski AM, and Scott MG. Transferrin/log (ferritin) ratio: a self-fulfilling prophecy when iron deficiency is defined by serum ferritin concentration. Clin Chem Lab Med. 2013, 51(5):e85-86. PMID: 23152417

Published abstracts (selected):

1. Ma C, Gilbertson JR, Becich MJ, and Monzon MA. Towards clinical applications of microarray analysis: effects of different target preparation methods on microarray based gene expression profiling. AMP Annual Meeting 2004. J Mol Diagn 2004 6(4): 438

2. Ma C, Sparano A, Quesnelle KM, Samanta M, Rao S, Puttaswamy K, Park MS, Kumar MS, Wang Y,

Weinstein GS, Feldman MD, and Brose MS. Complex CSMD1 gene alterations in primary head, neck

and lung carcinomas. AACR 2007

3. Ma C, and Lewis J. Small biopsy specimens reliably indicate p16 expression status of oropharyngeal squamous cell carcinoma - a biopsy and resection specimen correlation study. USCAP Annual Meeting 2011

4. Ma C, Krishnamurthy S, Dehner LP, and Lu D. Expression of CD10 and MMP-11 in the differential diagnosis of dermatofibroma variants and dermatofibrosarcoma protuberans. USCAP Annual Meeting 2012

5. Ma C, and Brunt EM. Sinusoidal obstruction syndrome injury in liver biopsies after hematopoietic cell transplantation. USCAP Annual Meeting 2013

6. Ma C, Montgomery EA, Stappenbeck TS, and, Liu TC. Small intestinal intermediate cells: spectrum of associated diseases and clinical implications. USCAP Annual Meeting 2014

7. Ma C, Giardiello FM, and Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are often associated with intestinal and pyloric differentiation. USCAP Annual Meeting 2014

8. Ma C, Park JY, Montgomery EA, Arnold CA, McDonald OG, Liu TC, Salaria SN, Limketkai BN, Mcgrath KM, Musahl T, and Singhi AD. Collagenous Gastritis: Do children present differently from adult onset patients? USCAP Annual Meeting 2015

9. Ma C, Chen CH, and Liu TC. A reappraisal of the gastric mucosal pathology in portal hypertensive patients. USCAP Annual Meeting 2015

10. Ma C, Maluf H, and Liu TC. Gastrointestinal graft versus host disease after stem cell transplantation: a comparison of the diagnostic yield of biopsy sites. USCAP Annual Meeting 2015