哈尔滨医科大学附属第二医院病理科副主任焦宇飞研究员
 教育简历 
 1980.9-1985.8    哈尔滨医科大学　　专业: 医疗　　学位: 学士
1987.9-1990.6    哈尔滨医科大学　　专业: 病理学　 学位: 硕士
1995.4-1999.3   日本 高知医科大学　　专业: 临床病理学　　学位: 博士.
 研究及工作简历
1985.7－1987.9 哈尔滨医科大学附属第二医院病理科住院医生
1990.7－1991.7哈尔滨医科大学基础医学院病理学教研室助教
1991.7－1994.2哈尔滨医科大学基础医学院病理学教研室讲师
1994.2－1995.3 日本高知医科大学第一病理学教室日本政府国费留学生
1999.4－2008.3 日本岩手医科大学临床病理部访问研究员

论著
1.           ＊Jiao YF, Nakamura S, Sugai T, Yamada N, Habano W. (2008) Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of histogenesis. Oncology. in press
2.           Habano W, Sugai T, Jiao YF, Nakamura S. (2007) Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy.　Int J Cancer. 121(7):1487-93. (IF, 4.693)
3.           Sugai T, Habano W, Jiao YF, Tsukahara M, Takeda Y, Otsuka K, Nakamura S. (2006) Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn. 8(2):193-201. (IF, 2.901)
4.           ＊Jiao YF, Sugai T, Habano W, Uesugi N, Takagane A, Nakamura S. (2006) Clinicopathological significance of loss of heterozygosity in intestinal- and solid-type gastric carcinomas: a comprehensive study using the crypt isolation technique. Mod Pathol. 19(4):548-55. (IF, 3.753)
5.           Ando T, Sugai T, Habano W, Jiao YF, Suzuki K. (2005) Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas. J Gastroenterol. 40(7):708-15. (IF, 1.927)
6.           Sugai T, Habano W, Jiao YF, Suzuki M, Takagane A, Nakamura S. (2005) Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers. Oncology. 68(4-6):548-57. (IF, 2.252)
7.           Sugai T, Habano W, Jiao YF, Suzuki M, Takagi R, Otsuka K, Higuchi T, Nakamura S. (2005) Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas. Int J Cancer. 114(3):337-45. (IF, 4.693)
8.           ＊Jiao YF, Sugai T, Habano W, Suzuki M, Takagane A, Nakamura S. (2004) Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique. J Pathol. 204(2):200-7. (IF, 5.759)
9.           Sugai T, Inomata M, Uesugi N, Jiao YF, Endoh M, Orii S, Nakamura S. (2004) Analysis of mucin, p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic lesions obtained from endoscopic mucosal resection samples: a proposal for a new classification of intramucosal neoplastic lesions based on nuclear atypia. Pathol Int. 54(6):425-35. (IF, 1.108)
10.       ＊Jiao YF, Sugai T, Suzuki M, Uesugi N, Habano W, Nakamura S, Takagane A, Suto T, Yoshida T. (2004) Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma. Hum Pathol. 35(5):587-93. (IF, 2.81)
11.       Jiao YF, Nakamura S, Arai T, Sugai T, Uesugi N, Habano W, Suzuki M, Tazawa H, Goukon Y. (2003) Adenoma, adenocarcinoma and mixed carcinoid-adenocarcinoma arising in a small lesion of the colon. Pathol Int. 53(7):457-62. (IF, 1.108)
12.       Sugai T, Uesugi N, Nakamura S, Habano W, Jiao YF, Noro A, Takahashi H, Akasaka I, Higuchi T. (2003) Evolution of DNA ploidy state and DNA index in colorectal adenomas and carcinomas using the crypt isolation technique: New hypothesis in colorectal tumorigenesis. Pathol Int. 53(3):154-62. (IF, 1.108)
13.       Sugai T, Habano W, Uesugi N, Jiao YF, Nakamura S, Sato K, Chiba T, Ishii M. (2002) Molecular validation of the modified Vienna classification of colorectal tumors. J Mol Diagn. 4(4):191-200. (IF, 2.901)
14.       Jiao YF, Nakamura S, Sugai T, Habano W, Uesugi N, Oikawa M, Sato T. (2002) p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum. APMIS. 110(2):165-71. (IF, 1.875)
15.       Jiao YF, Nakamura S, Sugai T, Uesugi N, Habano W, Ogata M, Fujioka T. (2002) Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case. Pathol Int. 52(2):135-40. (IF, 1.108)
16.       Sugai T, Habano W, Nakamura S, Jiao YF, Higuchi T, Inomata M, Chiba T. (2001) Analysis of Ki-ras gene mutations associated with DNA diploid, aneuploid, and multiploid colorectal carcinomas using a crypt isolation technique. Cytometry. 46(6):345-50. (IF, 2.065)
17.       Sugai T, Habano W, Uesugi N, Jiao YF, Nakamura SI, Yoshida T, Higuchi T. (2001) Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas. Oncogene. 20(42):6095-101. (IF, 6.582)
18.       ＊Jiao YF, Nakamura S, Oikawa T, Sugai T, Uesugi N. (2001) Sebaceous gland metaplasia in intraductal papilloma of the breast. Virchows Arch. 438(5):505-8. (IF, 2.251)
19.       Sugai T, Habano W, Nakamura S, Sato H, Uesugi N, Takahashi H, Jiao YF, Yoshida T, Itoh C. (2000) Genetic alterations in DNA diploid, aneuploid and multiploid colorectal carcinomas identified by the crypt isolation technique. Int J Cancer. 88(4):614-9. (IF, 4.693)
20.       Sugai T, Oikawa M, Uesugi N, Habano W, Jiao YF, Nakamura SI, Hatakeyama S, Suhara M, Hatafuku K. (2000) Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation. Pathol Int. 50(6):514-9. (IF, 1.108)
21.       ＊Jiao YF, Okumiya T, Saibara T, Kudo Y, Sugiura T. (2001) Erythrocyte creatine as a marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis. Clin Biochem. 34(5):395-8. (IF, 2.331)
22.       ＊Jiao YF, Okumiya T, Saibara T, Park K, Sasaki M. (1998) Abnormally decreased HbA1c can be assessed with erythrocyte creatine in patients with a shortened erythrocyte age. Diabetes Care. 21(10):1732-5. (IF, 7.912)
23.       Okumiya T, Jiao YF, Saibara T, Miike A, Park K, Kageoka T, Sasaki M. (1998) Sensitive enzymatic assay for erythrocyte creatine with production of methylene blue. Clin Chem. 44(7):1489-96. (IF, 5.454)
24.       ＊Jiao YF, Okumiya T, Saibara T, Tsubosaki E, Matsumura H, Park K, Sugimoto K, Kageoka T, Sasaki M. (1998) An enzymatic assay for erythrocyte creatine as an index of the erythrocyte life time. Clin Biochem. 31(2):59-65. (IF, 2.331)
 
(IF, from 2006 Journal Citation Reports)
 
主要学术成绩，创新点及其科学意义
 
1． 建立了一种敏感的，适用于日常临床实验室分析的红细胞内肌酸测定法（Jiao YF, Okumiya T, Saibara T, et al. An enzymatic assay for erythrocyte creatine as an index of the erythrocyte life time. Clin Biochem. 1998;31:59-65.）。使用这个方法，我们分析并证实了红细胞内肌酸可作为因红细胞寿命缩短（如溶血性贫血）而引起的HbA1c减少的一个用效的矫正指标（Jiao YF, Okumiya T, Saibara T, et al. Abnormally decreased HbA1c can be assessed with erythrocyte creatine in patients with a shortened erythrocyte age. Diabetes Care. 1998;21(10):1732-5.）。我们也证实，在有肝硬化病人，红细胞内肌酸可以预示造血状态和估计脾机能亢进（Jiao YF, Okumiya T, Saibara T, et al. Erythrocyte creatine as a marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis. Clin Biochem. 2001;34:395-8.）。
2． 在世界上首次报告了乳腺导管内乳头状瘤的皮脂腺化生。这项研究证实乳腺一种新的化生类型（Jiao YF, Nakamura S, Oikawa T, et al. Sebaceous gland metaplasia in intraductal papilloma of the breast. Virchows Arch. 2001;438:505-8.）。
3． 用腺管分离法分析了大样本胃癌流式细胞DNA 倍体类型与临床病理学表现的关系，我们的结果提示，和DNA 倍体类型相比，S-phase fraction可作为判定胃癌侵袭性的有效的指标（Jiao YF, Sugai T, Suzuki M, et al. Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma. Hum Pathol. 2004;35:587-93.）。
4． 用腺管分离法结合分子生物学的方法分析了胃癌的杂和性丢失（LOH）及微卫星不稳定性（MSI）。结果提示，腺管分离法是准确测定胃癌LOH的非常有效的方法，LOH和MSI常发生于肠型和实体型胃癌而少见于未分化型胃癌（Jiao YF, Sugai T, Habano W, et al. Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique. J Pathol. 2004;204:200-7.）。
5． 应用腺管分离法分析了胃癌的LOH与临床病理学表现的关系。结果提示，在肠型和实体型胃癌3p14, 4p15, 5q21-22, 9p21, 13q22 and 18q21的LOH同癌的发生有关，而1p36、8p11-12、17p31.1和22q13.31的LOH同肿瘤的进展有关（Jiao YF, Sugai T, Habano W, et al. Clinicopathological significance of loss of heterozygosity in intestinal- and solid-type gastric carcinomas: a comprehensive study using the crypt isolation technique. Mod Pathol. 2006;19:548-55.）。
6． 在世界上首次提出并证实了大肠锯齿状腺瘤同时存在增生和终末分化过程，而大肠锯齿状腺瘤独特的锯齿结构是由终末分化引起的 （Jiao YF, Nakamura S, Sugai T, et al. Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of histogenesis. Oncology，2008 in press）。