Dehua Wang   MD

Pathology and Laboratory Medicine

Cincinnati Children's Hospital

3333 Burnet Ave R2094, MLC 1035

Cincinnati, OH 45229

Dehua.wang2012@gmail.com（欢迎提问）

• EMPLOYMENT HISTORY

Staff pathologist, Assistant Professor  7/1/2014–Present

Pathology & Laboratory Medicine, Cincinnati Children’s Hospital, Cincinnati, Ohio

• EDUCATION

Pediatric Pathology Fellowship  7/1/2013 –6/30/2014

Pathology& Laboratory Medicine, Cincinnati Children’s Hospital, Cincinnati, Ohio

Hematopathology Fellowship  7/1/2012–6/30/2013

Pathology & Laboratory Medicine, Indiana University, Indianapolis, Indiana

Residencyin Anatomic and Clinical Pathology

Pathology& Laboratory Medicine, Boston University Medical Center, Boston, MA  7/1/2009–6/30/2012

Pathology&Laboratory Medicine, Drexel/Hahnemann University Hospital, Philadelphia  6/23/2008 –6/22/2009

Master of Science in Pathology  9/1/1993 –6/24/1996

Department of Pathology, Beijing Medical University, Beijing, P. R. China

Residency in Anatomic Pathology  7/1/1989 –8/31/1993

Department of Pathology, Tongji Medical Univ.Yunyang Medical College, Shiyan, Hubei, P. R. China

M.D.   9/1/1984 –6/25/1989

Tongji Medical UniversityYunyang Medical College, Shiyan, Hubei, P. R. China

• PROFESSIONAL EXPERIENCE

Postdoctoral Fellow

Department of Pediatric Oncology, Johns Hopkins University, Baltimore, MD  6/19/2003 –6/22/2008

Dept.of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN  11/15/2000 –6/18/2003

Associate Professor,Attending Pathologist, Vice Director  1/1/2000–10/31/2000

Department of Pathology, Yunyang Medical College, Taihe Hospital, Shiyan, Hubei, P. R. China

Staff Pathologist, Lecturer  7/1/1996–12/31/1999

Department of Pathology, Yunyang Medical College, Taihe Hospital, Shiyan, Hubei, P. R. China

Resident, Research Assistant   7/1/1989 –8/31/1993

Department of Pathology, Tongji Medical Univ. Yunyang Medical College, Shiyan, Hubei,P. R. China

• BOARD CERTIFICATIONS

9/25/2015Board Certified in Pediatric Pathology by the American Board of Pathology

9/26/2013Board Certified in Hematologyby the American Board of Pathology

8/2/2012Board Certifiedin Anatomic and Clinical Pathologyby the American Board of Pathology

8/9/2007ECFMG certified (PassedStep 1, Step 2 and Step 3)

• MEDICAL LICENSURE

7/19/13–10/01/19Ohio Physician License (35.121817)

1/26/12–10/31/17Indiana Physician license (01070619A)

12/10/13 –9/30/19Medical Board ofCalifornia-Physician and Surgeon A (128088)

• GRANTS

2006–2008NIH Ruth L. Kirschstein National Research Service Award (NRSA), NIH T32 Training Grant

1997–2000Hubei Provincial Public Health Department Grant, China

• HONORS AND AWARDS

2005 American Society of Hematology Travel Award

1998 The Outstanding Teacher of Hubei Province, China

1997, 1998 The Advanced Civilization Worker for Academic Excellence, Yunyang Medical College

1997 Fok Ying Tung Education Foundation-Hong Kong Summer School Training for Pathologist from China

1995 Excellent Graduate ScholarshipAward, Beijing Medical University

1992 The First Place Winner in the Teacher Speech Contest, Yunyang Medical College

1990 Advanced Academic Faculty ExcellenceAward, Yunyang Medical College

1985–1989 Outstandingand Excellent ScholarshipAwards, Tongji Medical University, Yunyang Branch

• PROFESSIONAL MEMBERSHIP

2016 –Present    Children’s Oncology Group(COG)

2016 –Present    Society of Pediatric Pathology

2012 –Present    American Society of Hematopathology

2009 –Present    United States and Canadian Academy of Pathology

2008–2014    College of American Pathologists

2008–2014    American Society of Clinical Pathology

2003–2008    American Society of Hematology

• INVITED TALK

3/08/2017  USCAP 2017short course Difficult diagnoses in pediatric hematopathology.

3/23/2016 Ann & Robert H. Lurie Children’s Hospital of ChicagoThe clonal relationship between histiocytic neoplasm and antecedent T-ALL

3/17/2016  USCAP 2016 short course Difficult diagnoses in pediatric hematopathology.

3/23/2018  USCAP 2018short courseDifficult diagnoses in pediatric hematopathology.

• PEER-REVIEWED PUBLICATION

1. Wang D, Marshall D, Veldtman G, Gupta A, Trout AT, Villafane J, Bove K. Intrahepatic Cholangiocarcinoma After Fontan Procedure in An Adult with Visceral Heterotaxy. Pathol Res Pract.2018 Mar 15. pii: S0344-0338(17)31255-4. doi: 10.1016/j.prp.2018.03.016. [Epub ahead of print]

2. Fang J, Bolanos LC, Choi K, Liu X, Christie S, Akunuru S, Kumar R, Wang D,Chen X, Greis KD, Stoilov P, Filippi MD, Maciejewski JP, Garcia-Manero G, Weirauch MT, Salomonis N, Geiger H, Zheng Y, Starczynowski DT.  Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nat Immunol.2017 Feb;18(2):236-245. doi: 10.1038/ni.3654.

3. Gong Z, Xie W, Wang W, Chen Z, Xu J, Yuan J, Zhou Y, Wang D,Medeiros LJ, HuS. T-lymphoid or T/myeloid blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy: a report of 14 cases.  Int J Lab Hematol.2017 Apr;39(2):e45-e50. doi: 10.1111/ijlh.12605.

4. Schaefer BA, Wang D,Merrow AC, Dickie BH, Adams DM. Long-term outcome for kaposiform hemangioendothelioma: A report of two cases. Pediatr Blood Cancer.2017 Feb;64(2):284-286. doi: 10.1002/pbc.26224.

5. Shammassian B, Manjila S, Cox E, Onwuzulike K, Wang D, Rodgers M, Stearns D, Selman WR.Mature salivary gland rests within sonic hedgehog-positive medulloblastoma: case report and insights into the molecular genetics and embryopathology of ectopic intracranial salivary gland analogs. J Neurosurg Pediatr.2016 Dec;25(6):708-712.

6. Mei Y, Zhao B, Yang J, Gao J, Wickrema A, Wang D, Chen Y, Ji PIneffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice. Haematologica.2016 Jan;101(1):e1-5. doi: 10.3324/haematol.2015.134221.

7. Zhou J, Wang D, Nassiri M. Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis.  Case Rep Pathol.2015;2015:513968. doi: 10.1155/2015/513968.

8. Weaver KN, Wang D, Cnota J, Gardner N, Stabley D, Sol-Church K, Gripp KW, Witte DP, Bove KE, Hopkin RJ. Early-lethal Costello syndrome due to rare HRAS Tandem Base substitution (c.35_36GC>AA; p.G12E)-associated pulmonary vascular disease. Pediatr Dev Pathol.2014;17(6):421-30.

9. WangD, Lane C, Quillen KPrevalence of RhD variants, confirmed by molecular genotyping, in a multi-ethnic prenatal populationAm J Clin Pathol.2010;134:438-442.

10. WangD,Paz-Priel I, and Friedman AD    NF-κ B p50 Regulates C/EBPα Expression and Inflammatory Cytokine-Induced Neutrophil ProductionThe Journal of Immunology2009;182(9):5757-5762

11. Cai DH, Wang D,Keefer J, Yeamans C, Hensley K, and Friedman AD.     C/EBP:AP-1 Leucine Zipper Heterodimers BindNovel DNA Elements, Activate the PU.1 Promoter, and Direct Monocyte Lineage Commitment More Potently Than C/EBPα Homodimers or AP-1   Oncogene 2008;27(19):2772-9

12. Yeamans C, Wang D, Paz-Priel I, Torbett BE, Tenen DG, Friedman AD.     C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood2007;110 (9):3136-3142

13. Wang D, D'Costa J, Civin CI, and Friedman AD.C/EBPα directs monocytic commitment of primary myeloid progenitorsBlood2006;108(4): 1223 –1229

14. Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A.Autophagy delays apoptotic death in breast cancer cells following DNA damage Cell Death and Differentiation 2006;14(3):500-510

15. Paz-Priel I, Cai DH, Wang D, Kowalski J, Blackford A, Liu H, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman ADC/EBPα and C/EBPα myeloid oncoproteins induce Bcl-2 via interaction of their basic regions with NF-κ B p50.   Mol. Cancer Res. 2005;3 (10): 585-596

16. Wang D, McDonnell MA, Kelekar A.Multi-probe RPA template sets to study RNA modulation and transcriptional control of BH3-only members of the Bcl-2 familyCancer Detection and Prevention2005;29(2), 189-200

17. McDonnell MA, Wang D, Khan SM, Vander Heiden MG, Kelekar A.   Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells   Cell Death and Differentiation 2003;10(9):1005 –1015

18. Wu Q, Li S, Wang Q and Wang Det al, The expression of COX-2 in esophageal carcinoma and its relation to clinicopathologic characteristics.   World Chinese Journal of Digestology2001;9 (9): 11-14

19. Wang D,Liao S, Gao Z et al The relationship among neovascularization, Ki-67 antigen, p53 protein expression and DNA relative content in non-small cell lung cancer.    Cancer Research and Clinic1999;11 (supplement): 1-2

20. Wang D,Liao S, Gao Z   The study on the correlation of the labeling rate of Ki-67 antigen and the prognosis in non-small cell lung cancer.  Chinese Journal of Clinical Oncology 1999;26(4):309-310

21. Wang D,Liao S, Gao Z et al.  The Prognostic significance of p53 protein expression and gene mutation in non-small cell lung cancer.  Journal of Practical Oncology1998;13(6): 330-333

22. Wang D, Liao S, Gao Z et al.  The Prognosticvalue of DNA relative content detected by image analysis cytometry in non-small cell lung carcinoma.   Chinese Journal of Clinical Oncology 1998;25(11): 844

23. Wang D, Zhang H, Liao S et al.   Study of the concordance of immunohistochemistry and PCR-SSCP detecting p53 gene abnormality.   Chinese Journal of Clinical and Experimental Pathology 1998;14(4): 350-352

24. Wang D,Gao Z, Liao S et al.   The methodological study of factor VIII related antigen staining in detection of neovascularization of tumor     Chinese Journal of histochemistry and cytochemistry1998;7(3): 360-363

25. Wang D,Bai Y, Liao S et al.  The study of p53 gene mutation associated with clinicopathological characteristics in lung adenocarcinoma.   China Oncology1998;8(3): 199-201

26. Wang D,Liao S, Gao Z et al.   Relationship of blood vessel and lymphatic vessel invasion to prognosis of non-small cell lung cancer in stage I and II.   Cancer Research on Prevention and Treatment1998;25(4): 267-269

27. Wang D, Liao S, Gao Z et al.  Prognostic significance of DNA relative content in non-small cell lung carcinoma.     Journal of Yunyang Medical College1998;17(1): 6-8

28. Wang D,Liao S, Gao Z et al.  The Prognostic significance of p53 gene abnormality in 85 cases non-small cell lung cancer.   Journalof Yunyang Medical College 1998;17(2):65-68

29. Wang D,Liao S, Gao Z et al.  Multivariate analysis of prognostic factors in non-small cell lung cancer.  Zhonghua Yi Xue Za Zhi.1997 Jul;77(7):497-500.

30. Wang D,Liao S   Metastasis related factors and prognosis of lung cancer. A review.  Foreign Medical Sciences (Pathophysiology and Clinical Medicine)1997;17 (3): 203-6

31. Wang D,Liao S, Gao Z et al.  Study on the relationship of tumor neovascularization count to biological behavior and prognosis of non-small cell lung cancer. Chinese Journal of Clinical and Experimental Pathology1997;13(4): 308-310

32. Wang D,Liao S, Gao Z et al. The study of the polyclonal antibody Ki-67 estimating tumor proliferative activity and prognosis in non-small cell lung cancer.  Journal of Diagnostic Pathology 1997;4(2): 77-9

33. Wang D, Liao S Proliferation activity related factors and prognosis of lung cancer.  A review.  Foreign Medical Sciences (Oncology Section)1997;24(supplement): 225-228.15

34. Wang D, Liao S.   The major biological prognostic factors of lung cancer. A review.  Journal of Yunyang Medical College1995;14(2): 119-24

• ORAL PRESENTATION

Dehua Wang,Robert Lorsbach Azathioprine-induced immunodeficiency associated polymorphic/lymphoplasmacytic LPD. 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology. Oral platform presentation.

• ABSTRACT

Catherine Socec, Richard McMaster,Dehua Wang  Clinicopathologic and Genomic Characteristics of Two Cases of Pediatric Histiocytic Neoplasms Following T-ALL  Poster presented at: USCAP 2017, March 7th, 2017, San Anthonio

Blachy J Davila Saldana, Christopher Dandoy, Dehua Wang,Amy Sheil, Sharat Chandra, and Ashish R. Kumar.Lymphoproliferative Disease Masquerading as HLH in Crohn's Disease2015 Clinical Immunology Society (CIS) Annual Meeting.

Dehua Wang,Robert J Hopkin, Emily King, Lili Miles, Maria A Calvo-Garcia, Jerzy Stanek  Pena-Shokeir Phenotype/ Fetal Akinesia Deformation Sequence: From Placenta to Secondary Myopathy.Poster presented at: 2014 IFPA meeting, September 8-12, Paris, France.

April Chiu, Magdalena Czader, Rachel C Ochs, Dehua Wang, David C Park, Jungbluth A Achim, Denise Frosina, Aarti Goswami, Teruya-Feldstein Julie and Attilio OraziSubtypes of systemic mastocytosis exhibit distinct immunomorphologic features in bone marrow biopsies. Poster presentedat:USCAP meeting, March 2-8, 2013. Baltimore, MD

WangD, Lee J, Soo Hoo PT, Connors LH, O’Hara CJ  The reliability and accuracy of immuno-gold electron microscopy for subtyping amyloid; correlation with laboratory studies and clinical setting.Poster presented at: USCAP meeting, February 26-March 4, 2011, San Antonio, TX

WangD, Lane C, Quillen KPrevalence of RhD variants, confirmed by molecular genotyping, in a multi-ethnic prenatal population Poster presented at: CAP’10 pathologists’ meeting, September 26-29 Chicago, IL

Wang D, D'Costa J, Civin CI, and Friedman AD. (2005, December). C/EBPa directs monocytic commitment of primary myeloid progenitors. Poster presented at: American Society of Hematology; Atlanta, GA.

Wang D, Friedman AD. (2004, December). Exogenous C/EBPa Increase the Monocytic Maturation of Normal Murine Myeloid Progenitors. Poster presented at: American Society of Hematology; San Diego, CA.

Wang D, Khan SM and Kelekar A. (2001, November). Regulation of mRNA expression of BH3 Domain-containing pro-apoptotic members of the Bcl-2 family during apoptosis. Poster presented at: Cold Spring Harbor Laboratory; New York City, NY.

Wang D, Liao S, Gao Z et al. (1997, October). Multivariate analysis and study of clinical, pathological and biological prognostic factors in stage I and II non-small cell lung cancer. Poster presented at: International Academy of Pathology Chinese Division and Chinese Society of Pathology, Chinese Medical Association; Shanghai, China.

Wang D, Liao S, Gao Z et al. (1997, October). Relationship of blood vessel and lymphatic vessel invasion to prognosis of non-small cell lung cancer in stage I and II. Poster presented at: International Academy of Pathology Chinese Division and Chinese Society of Pathology, Chinese Medical Association; Shanghai, China.

• RESEARCH AND TEACHING EXPERIENCE

Cincinnati Children’s Hospital/University of Cincinnati Medical Center7/2014-present

Didactic teaching to pathology residentstwice year

Teachingpediatric pathology/Hem/Oncfellows,pathology/medicalresidents and medical students.

Cincinnati Children’s Hospital, Pediatric Pathology fellow7/2013 –6/2014

Project: 1)Histiocytic neoplasms clonally related toPreceding T-cell acute lymphoblastic leukemia

2) Costello Syndrome: a Disorder of Elastogenesis Causing Pulmonary Vascular Dysplasia

3) Pena-Shokeir Phenotype/ Fetal Akinesia Deformation Sequence: From Placenta to Secondary Myopathy

Teaching activities:Taught lab course to graduate students

Indiana University, Hematopathology Fellow7/2012–6/2013

Project: Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disorder

Teaching activities:Regularly scheduled for teachinghematopathology lab courses to medical students, and lectures to residents; taught/supervised residents during their hematopathology rotation

Boston University, AP/CP Resident7/2009–6/2012

Projects:1) Prevalence of RhD variants, confirmed by molecular genotyping,in a multi-ethnic prenatal population.

2) Amyloidtyping by electron immunogold labeling correlates with clinical laboratory data in amyloidosis patients.

Teaching activities:Occasionally taught lab courses to medical students; taught medical students during their rotation

Drexel University, AP/CP Resident6/2008–6/2009

Teaching activities:Occasionally taught lab courses to pathology assistant students; taught medical students during their rotation 

Johns Hopkins, Postdoctoral and Research Fellow6/2003–6/2008

Projects:1) Role of C/EBPα NF-κ B interaction in myeloid development and transformationSupported by NIH T32 training grant

2) Regulation of myelopoiesis by transcriptional factor C/EBPα 

3) C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.

4) C/EBPα and C/EBPα myeloid oncoproteins induce Bcl-2 via interaction of their basic regions with NF-κ B p50.

University of Minnesota, Postdoctoral Associate11/2000–6/2003

Projects:1) Regulation of BH3-only protein of the Bcl-2 family during apoptosis

2) The mechanism underlying the observed cytochrome c-independent activation of the caspase-9 protein in murine pro B lymphoma cells. 

Yunyang Medical College, Faculty 7/1996 –10/2000

Project:Multivariate analysis of prognostic factors in non-small cell lung cancer

Teaching activities:Taught the anatomic pathology lab courses to medical students and graduate students

Beijing Medical University, Graduate student, Teaching Assistant & Research Assistant9/1993–6/1996

Project:Multivariate analysis of prognostic factors in non-small cell lung cancer

Teaching activities:Taught the anatomic pathology lab courses to medical students

Tongji Medical UniversityYunyang Branch, Resident9/1989–8/1993

Research and teaching activity:Taught the anatomic pathology lab courses and lecture series to medical students; participated and assisted in the professor’s research project

• HOBBIES AND PERSONAL INTERESTS

Tennis, basketball, aerobics, Pilates, yoga, swimming, listen music and travel.

（网球，篮球，健美操，普拉提，瑜伽，游泳，听音乐和旅游。）