Yuan (Frank) Shan, M.D., Ph.D.
教育经历：
1990-1995 Ph.D.         神经系统科学，Wayne State University, Detroit, Michigan, USA
1980-1985 M.D.      第二军医大学，上海
专业培训
1985 - 1990                病理住院医师，北京301医院
1995 - 1999                住院医师，病理科，Strong Memorial Hospital, University of Rochester, Rochester, New York
1999 - 2001                 Fellow,神经病理学，Strong Memorial Hospital, University of Rochester, Rochester, New York
工作经历
1996 - 2001                 神经病理会诊医生，Consultant neuropathologist, Rochester Alzheimer's Disease Research Center/Brain Bank, University of Rochester, Rochester, New York
1996 - 2001                 病理主治医生，兼职，活检服务， Strong Memorial Hospital and Rochester General Hospital, Rochester, New York
2001 - 2007                 病理/神经病理主治医生，Ameripath Indiana, Indianapolis, Indiana
2008 至今                  病理主治医生，Collier Pathology Service, Naples, Florida
专业学术团体任职：
美国病理医师协会会员
美国临床病理医师社团成员
全美神经病理医师协会会员
加拿大神经病理医师协会会员
教学经历：
医学生解剖与神经解剖学实验室，Wayne State University, Detroit, Michigan, 1990-1994
医学生普通病理学实验室，University of Rochester, Rochester, New York, 1995-2000
医学生、住院医师和fellow的神经病理学教学， University of Rochester, Rochester, New York, 1999-2001
住院医师神经解剖学与神经病理学教学， Indiana Neuroscience Institution
Publications
Shan Y, Li WH. Laminin distribution in squamous cell carcinoma of the esophagus: An immunohistochemical study. Chin J Oncol 12: 339-342, 1990
Shan Y.  Laminin distribution in the clonal cells of PL-801 (pulmonary giant cell carcinoma cell line) and its effect on tumor cell migration. Chin J Pathol 20: 122-126, 1991
单远, 李维华. 肺腺鳞癌的光镜与电镜研究. 临床与实验病理学杂志8:186-188 1992
Carlock LR, Walker PD, Shan Y, Gutridge K.  Transcriptional response of the Huntington disease gene (IT15) during the initial stages of the quinolinic acid excitotoxic cascade.  NeuroReport. 6: 1121-1124, 1995
Shan Y, Carlock LR, Walker PD. NMDA receptor overstimulation triggers a prolonged wave of immediate early gene expression: relationship to excitotoxicity. Exp Neurol 144: 406-415, 1997
Reisenfeld EP, Shan Y, Pietropaoli AP. Pathology Quiz Case: Infection in a patient with a cervical arteriovenous malformation.  Arch Pathol Lab Med 124: 466-468, 2000
Rumbaugh JA, LaDuca JR, Shan Y, Miller C.  CADISIL: The dermatologic diagnosis of a neurologic disease.  J Am Acad Dermatol. 43: 1128-1130, 2000
单远. 美国病理医生的医疗失误及其保险系统. 中华病理学杂志 32: 491-494, 2003

Owor G, Qian J, Payner T, Martin A, Shan Y. Intracranial neuromuscular choristoma. A case report and literature review. ENT J (accepted)
Fung KM, Payner T, Shan Y. Rhabdoid glioblastoma in an adult patient. (in preparation)
Shan Y, Felgar R, Cohen P, Vnencak-Jones CL, Powers JM. Primary central nervous system CD4+ cytotoxic T cell lymphoma with prominent eosinophilic cells. (in preparation)
Abstracts and Poster Presentations
Shan Y, Walker PD, Carlock LR. A second phase of intermediate-early gene expression correlates with neuronal loss and glial/immune response in the Huntington's disease model. Soc Neurosci Abstr 18: 167, 1992
Shan Y, Carlock LR, Walker PD. Delayed immediate early gene activation and the excitotoxic cascade. Soc Neurosci Abstr 19: 1774, 1993
Walker PD, Shan Y, Lorincz M, Carlock LR. Application of the excitotoxic rodent model to studies on the Huntington's disease gene, 15th International World Federation of Neurology Workshop on Huntington's Disease, 1993
Shan Y, Carlock LR, Walker PD. Prolonged immediate early gene transcription correlates with neuronal death during the NMDA receptor-mediated excitotoxic cascade. Soc Neurosci Abstr 20:271, 1994
Carlock LR, Gutridge K,  Shan Y, Walker, PD. Timing the transcriptional response of the IT15 gene (Huntington) during the early stages of the NMDA receptor mediated excitotoxic cascade. Soc Neurosci Abstr 20:1255, 1994
Walker PD,  Shan Y,  Sall JM, Goldman H, Underwood BD,  Dutcher SA, Michael DB. Immediate early gene activation during brain injury: passive phenomenon or active participant in cell death. 6th Annual Spring Brain Conference, Sedona, Arizona, 6: 15, 1995
Shan Y, Saunders CA, Rubio A, Powers JM. Aspergillus of the middle cerebral artery trification mimicking a saccular aneurysm. J Neuropath Exp Neurol. 56 (5): 621, 1997
Shan Y, Rubio A, Stewart JM, Powers JM. Differentiating hemangioblastoma from renal cell carcinoma by immunocytochemistry staining.  J Neuropath Exp Neurol.  57 (5): 526, 1998
Padula A,  Shan Y, Rubio A, Powers JM. Herpes simplex encephalitis with vermal and limbic involvement.  J Neuropath Exp Neurol.  57 (5): 481, 1998
Shan Y, Alvarez V, Powers JM. Chiare type I malformation associated with sleep apnea and sudden death.  J Neuropath Exp Neurol.  58 (5): 521, 1999
Deng AC, Shan Y, Rezaiamiri S, Meyers SP, Okawara SH, Rubio A. Intradural extramedullary primitive neuroectodermal tumor (PNET) of thoracic spinal canal: A case report. J Neuropath Exp Neurol. 59 (5): 443, 2000
Korones DN, Shan Y, Benita-Weiss M, Teot LA, Powers JM. P-Glycoprotein is expressed in primitive neuroectodermal tumors and tumor endothelial cells.  Neuro-oncology 2: 275, 2000
Shan Y, Felgar R, Cohen P, Vnencak-Jones CL, Powers JM. Primary central nervous system CD4+ cytotoxic T cell lymphoma with prominent eosinophilic cells. J Neuropath Exp Neurol. 60 (5): 525, 2001
Moritani T, Numaguchi Y, Powers JM, Ito M, Shan Y, Wang HZ, Shibata DK, Westesson PA, Shrier DA.  Diffuse weighted-echo planar MR imaging in CNS infection.  ASNR Annual Meeting, 2001
Shan Y, Martin A, Payner T, Qian J. Intracranial facial nerve rhabdomyoma/neuromuscular choristoma, A case report. J. Neuropath Exp Neurol . 60 (5): 522, 2002
Shan Y, and Fung KM. High-grade glial tumor with rhabdoid morphology in an adult patient.   J. Neuropath Exp Neurol, 61 (5): 524, 2003
Other Presentations

1. Huntington Disease, Past, Current and Future.
Department of  Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA, 1997
2. Differentiating hemangioblastoma from renal cell carcinoma, An immunohistochemical Study.
Department of  Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA, 1998
3. Ezrin, A New Marker in the Diagnosis and Grading of Glial Neoplasms.
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA, 2000
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.
New Brunswick, New Jersey, USA, 2001
4. 美国病理医生的医疗事故及保险系统:
北京协和医院病理科, 2002
北京301 医院病理科, 2002
5. 冰冻切片和术中会诊:
北京协和医院病理科, 2002
北京协和医院普通外科, 2002
北京朝阳医院, 2003.
6. 染色体 1p 和 19q 的缺失在脑胶质瘤中的检测和意义.
北京协和医院病理科, 2002
北京301 医院病理科, 2003
第八届中华病理学年会, 中国, 济南, 2004
7. 如何在冰冻切片中避免重大诊断失误: 一点美国的经历.
第八届中华病理学年会, 中国, 济南, 2004